What the FDA labels say about taking them together
Isavuconazonium and midazolam
Isavuconazonium's FDA label of April 25, 2025 names midazolam in its drug interactions section; the midazolam labels PlainMeds reads (4) do not name isavuconazonium. The isavuconazonium label: “Midazolam Use with Caution Concomitant administration of CRESEMBA and midazolam results in increase in midazolam exposure.”
Check it at the source: the isavuconazonium FDA label on DailyMed (effective April 25, 2025, Astellas Pharma US, Inc.); the midazolam FDA label on DailyMed (effective January 1, 2024, Fresenius Kabi USA, LLC).
What does the isavuconazonium label say about midazolam?
Isavuconazonium label, drug interactionsMidazolam Use with Caution Concomitant administration of CRESEMBA and midazolam results in increase in midazolam exposure.
Source: FDA drug label (CRESEMBA), Astellas Pharma US, Inc., effective April 25, 2025 (SPL set 8f7f73b8-586a-4df0-935f-fecd4696c16c), via openFDA; the full label on DailyMed
What does the midazolam label say about isavuconazonium?
Midazolam's label (effective January 1, 2024) and its 3 other brand-application labels do not name isavuconazonium in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Midazolam), Fresenius Kabi USA, LLC, effective January 1, 2024 (SPL set 1cc9ba6e-fa1b-405e-9de8-720c567b2a73), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Isavuconazonium | Midazolam | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $114.00 per capsule 186 mg capsule | $0.233 per mL 2 mg/2 mL vial |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once