Isavuconazonium and Midazolam Interaction
Drug interaction information between Isavuconazonium and Midazolam.
Isavuconazonium and Midazolam have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Isavuconazonium and Midazolam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Isavuconazonium slows down the breakdown of midazolam, which leads to higher levels of the sedative in your blood. This can make the drug's effects much stronger or last longer than intended.
FDA Label Information
Midazolam Use with Caution Concomitant administration of CRESEMBA and midazolam results in increase in midazolam exposure. Consider dose reduction of midazolam when isavuconazole is coadministered [see Clinical Pharmacology ( 12.3 )] .
Isavuconazonium Also Interacts With
- Itraconazole major
- Atorvastatin moderate
- Bupropion moderate
- Cyclosporine moderate
- Digoxin moderate
Midazolam Also Interacts With
- Darunavir major
- Itraconazole major
- Nirmatrelvir/Ritonavir major
- Ketoconazole moderate
- Verapamil moderate
Frequently Asked Questions
What SPL severity band is on file for Isavuconazonium + Midazolam?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Midazolam has 39 labeled pairs on file vs Isavuconazonium's 9. In the moderate band specifically: Isavuconazonium has 5 (also Atorvastatin, Bupropion, Cyclosporine, Digoxin); Midazolam has 9 (also Ketoconazole, Verapamil, Erythromycin, Ranitidine).
What mechanism field is on file for Isavuconazonium and Midazolam?
Isavuconazonium slows down the breakdown of midazolam, which leads to higher levels of the sedative in your blood. This can make the drug's effects much stronger or last longer than intended.
Midazolam carries more major-labeled pairs than Isavuconazonium
SPL source-record counts only. This page's band is moderate · classes on file: Isavuconazonium (Azole Antifungal); Midazolam (Benzodiazepine).
Midazolam has 3 major-labeled pairs vs Isavuconazonium's 1. This page itself is in the moderate band, not the major band.
1 major · 5 moderate · 3 minor · 9 total
- Other moderate peers for Isavuconazonium
- Atorvastatin
- Bupropion
- Cyclosporine
- Digoxin
3 major · 9 moderate · 27 minor · 39 total
- Other moderate peers for Midazolam
- Ketoconazole
- Verapamil
- Erythromycin
- Ranitidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.