Isavuconazonium and Itraconazole Interaction
Drug interaction information between Isavuconazonium and Itraconazole.
Isavuconazonium and Itraconazole have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Isavuconazonium and Itraconazole. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Itraconazole blocks the body's ability to break down isavuconazonium, which can cause the drug to reach unsafe levels.
What To Do
Do not take these medicines together, and wait two weeks after stopping itraconazole before starting the new drug.
FDA Label Information
Antihelminthics, Antifungals and Antiprotozoals Isavuconazonium Contraindicated during and 2 weeks after itraconazole treatment.
Isavuconazonium Also Interacts With
- Atorvastatin moderate
- Bupropion moderate
- Cyclosporine moderate
- Midazolam moderate
- Digoxin moderate
Itraconazole Also Interacts With
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
- Felodipine major
Frequently Asked Questions
Can I take Isavuconazonium and Itraconazole together?
This is a major interaction. Do not take these medicines together, and wait two weeks after stopping itraconazole before starting the new drug.
How serious is the interaction between Isavuconazonium and Itraconazole?
This interaction is classified as "major" severity by the FDA. Major interactions may be life-threatening or cause serious side effects.
Why do Isavuconazonium and Itraconazole interact?
Itraconazole blocks the body's ability to break down isavuconazonium, which can cause the drug to reach unsafe levels.
Understanding the Isavuconazonium and Itraconazole Interaction
FDA-approved prescribing information for these two drugs flags their combination as a major-severity interaction. Isavuconazonium belongs to the Azole Antifungal class and Itraconazole belongs to the Azole Antifungal class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Itraconazole blocks the body's ability to break down isavuconazonium, which can cause the drug to reach unsafe levels. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Isavuconazonium has 9 total documented interactions on file in this dataset, and Itraconazole has 116. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Do not take these medicines together, and wait two weeks after stopping itraconazole before starting the new drug. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Isavuconazonium or Itraconazole based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.