hydrochlorothiazide/losartan vs lisinopril
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Side-by-side comparison of hydrochlorothiazide/losartan and lisinopril. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
The Veterans Affairs Nephropathy in Diabetes (VA NEPHRON-D) trial enrolled 1448 patients with type 2 diabetes, elevated urinary-albumin-to-creatinine ratio, and decreased estimated glomerular filtration rate (GFR 30 to 89.9 mL/min), randomized them to lisinopril or placebo on a background of losartan therapy and followed them for a median of 2.2 years. Patients receiving the combination of losartan and lisinopril did not obtain any additional benefit compared to monotherapy for the combined endpoint of decline in GFR, end-stage renal disease, or death, but experienced an increased...
Hyzaar
Prinivil, Zestril
Hyzaar is a combination medicine that contains losartan and hydrochlorothiazide. It is used to lower high blood pressure.
No summary available.
Hyzaar is used to treat high blood pressure. Lowering blood pressure reduces your risk of strokes and heart attacks. It is also used to lower the risk of stroke in patients with high blood pressure and an enlarged left ventricle of the heart.
Information not available.
Losartan blocks a substance in your body that tightens blood vessels. This helps blood vessels relax, which lowers blood pressure. Hydrochlorothiazide is a diuretic that helps your body get rid of extra salt and water, which also lowers blood pressure.
Information not available.
- • Dizziness
- • Upper respiratory infection
- • Cough
- • Back pain
- • Dizziness
- • Headache
- • Cough
- • Feeling tired
- • Diarrhea
- Tiredness 10,013
- Feeling sick to your stomach 9,706
- Loose stools 8,311
- Discomfort 7,665
- Difficulty breathing 7,584
- Fatigue 19,346
- Nausea 17,996
- Diarrhoea 16,771
- Dyspnoea 13,650
- Pain 13,303
If you are pregnant or plan to become pregnant, stop taking Hyzaar and tell your doctor right away. This medicine can harm or kill your unborn baby.
No specific warnings noted.
Do not take Hyzaar if you are pregnant. It can cause serious harm to your unborn baby, including kidney problems, lung problems, skeletal problems and even death. If you are breastfeeding, talk to your doctor about whether Hyzaar is right for you.
No pregnancy information available.
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How to Read This hydrochlorothiazide/losartan vs lisinopril Comparison
hydrochlorothiazide/losartan is classified in the Thiazide Diuretic / ARB Combination drug class, while lisinopril sits within the ACE Inhibitor class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, hydrochlorothiazide/losartan has 43,279 submissions while lisinopril has 81,066. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to combining these two similar types of blood pressure drugs does not offer extra protection for your heart or kidneys and increases the risk of side effects.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for hydrochlorothiazide/losartan or lisinopril.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.