Hydrochlorothiazide/Lisinopril and Lisinopril Interaction
Drug interaction information between Hydrochlorothiazide/Lisinopril and Lisinopril.
Hydrochlorothiazide/Lisinopril and Lisinopril have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Hydrochlorothiazide/Lisinopril and Lisinopril. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Taking these medicines together can cause your blood pressure to drop to an unsafe level, especially when you first start the treatment.
What To Do
Your doctor may need to adjust your salt intake or change your dose to prevent your blood pressure from falling too low.
FDA Label Information
Drug Interactions Lisinopril Hypotension - Patients on Diuretic Therapy: Patients on diuretics and especially those in whom diuretic therapy was recently instituted, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with lisinopril. The possibility of hypotensive effects with lisinopril can be minimized by either discontinuing the diuretic or increasing the salt intake prior to initiation of treatment with lisinopril. If it is necessary to continue the diuretic, initiate therapy with lisinopril at a dose of 5 mg daily, and provide close...
Hydrochlorothiazide/Lisinopril Also Interacts With
- Aliskiren major
- Losartan minor
- Hydrochlorothiazide minor
- Spironolactone minor
- Propranolol minor
Lisinopril Also Interacts With
- Hydrochlorothiazide major
- Aliskiren major
- Losartan minor
- Spironolactone minor
- Propranolol minor
Frequently Asked Questions
Can I take Hydrochlorothiazide/Lisinopril and Lisinopril together?
This is a minor interaction. Your doctor may need to adjust your salt intake or change your dose to prevent your blood pressure from falling too low.
How serious is the interaction between Hydrochlorothiazide/Lisinopril and Lisinopril?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Hydrochlorothiazide/Lisinopril and Lisinopril interact?
Taking these medicines together can cause your blood pressure to drop to an unsafe level, especially when you first start the treatment.
Understanding the Hydrochlorothiazide/Lisinopril and Lisinopril Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Hydrochlorothiazide/Lisinopril belongs to the Thiazide Diuretic / ACE Inhibitor Combination class and Lisinopril belongs to the ACE Inhibitor class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Taking these medicines together can cause your blood pressure to drop to an unsafe level, especially when you first start the treatment. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Hydrochlorothiazide/Lisinopril has 13 total documented interactions on file in this dataset, and Lisinopril has 15. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor may need to adjust your salt intake or change your dose to prevent your blood pressure from falling too low. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Hydrochlorothiazide/Lisinopril or Lisinopril based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.