Hydrochlorothiazide and Lisinopril Interaction
Drug interaction information between Hydrochlorothiazide and Lisinopril.
Hydrochlorothiazide and Lisinopril have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Hydrochlorothiazide and Lisinopril. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these medicines together can cause your blood pressure to drop to an unsafe level, especially when you first start the treatment.
FDA Label Information
Drug Interactions Lisinopril Hypotension - Patients on Diuretic Therapy: Patients on diuretics and especially those in whom diuretic therapy was recently instituted, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with lisinopril. The possibility of hypotensive effects with lisinopril can be minimized by either discontinuing the diuretic or increasing the salt intake prior to initiation of treatment with lisinopril. If it is necessary to continue the diuretic, initiate therapy with lisinopril at a dose of 5 mg daily, and provide close...
Hydrochlorothiazide Also Interacts With
- Aliskiren major
- Losartan minor
- Hydrochlorothiazide minor
- Spironolactone minor
- Propranolol minor
Lisinopril Also Interacts With
- Hydrochlorothiazide major
- Aliskiren major
- Losartan minor
- Spironolactone minor
- Propranolol minor
Frequently Asked Questions
What SPL severity band is on file for Hydrochlorothiazide/Lisinopril + Lisinopril?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lisinopril has 15 labeled pairs on file vs Hydrochlorothiazide's 13. In the minor band specifically: Hydrochlorothiazide has 12 (also Losartan, Hydrochlorothiazide, Spironolactone, Propranolol); Lisinopril has 13 (also Losartan, Spironolactone, Propranolol, Lithium).
What mechanism field is on file for Hydrochlorothiazide/Lisinopril and Lisinopril?
Taking these medicines together can cause your blood pressure to drop to an unsafe level, especially when you first start the treatment.
Lisinopril carries more major-labeled pairs than Hydrochlorothiazide
SPL source-record counts only. This page's band is minor · classes on file: Hydrochlorothiazide (Thiazide Diuretic / ACE Inhibitor Combination); Lisinopril (ACE Inhibitor).
Lisinopril has 2 major-labeled pairs vs Hydrochlorothiazide's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 12 minor · 13 total
- Other minor peers for Hydrochlorothiazide
- Losartan
- Hydrochlorothiazide
- Spironolactone
- Propranolol
2 major · 0 moderate · 13 minor · 15 total
- Other minor peers for Lisinopril
- Losartan
- Spironolactone
- Propranolol
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.