hydrochlorothiazide/lisinopril vs lisinopril
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Side-by-side comparison of hydrochlorothiazide/lisinopril and lisinopril. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Drug Interactions Lisinopril Hypotension - Patients on Diuretic Therapy: Patients on diuretics and especially those in whom diuretic therapy was recently instituted, may occasionally experience an excessive reduction of blood pressure after initiation of therapy with lisinopril. The possibility of hypotensive effects with lisinopril can be minimized by either discontinuing the diuretic or increasing the salt intake prior to initiation of treatment with lisinopril. If it is necessary to continue the diuretic, initiate therapy with lisinopril at a dose of 5 mg daily, and provide close...
Zestoretic
Prinivil, Zestril
Zestoretic is a drug that combines lisinopril and hydrochlorothiazide. It is used to treat high blood pressure.
No summary available.
Zestoretic is used to treat high blood pressure. Lowering blood pressure reduces the risk of heart problems and strokes. Controlling high blood pressure should also include managing cholesterol, diabetes, and quitting smoking. Many people need more than one medicine to control their blood pressure.
Information not available.
Zestoretic contains two medicines. Lisinopril is an ACE inhibitor that widens blood vessels. Hydrochlorothiazide is a diuretic that helps your body get rid of extra salt and water, which also lowers blood pressure.
Information not available.
- • Dizziness
- • Headache
- • Cough
- • Feeling tired
- • Dizziness
- • Headache
- • Cough
- • Feeling tired
- • Diarrhea
- Feeling tired 10,013
- Feeling sick to your stomach 9,706
- Loose stools 8,311
- Discomfort 7,665
- Difficulty breathing 7,584
- Fatigue 19,346
- Nausea 17,996
- Diarrhoea 16,771
- Dyspnoea 13,650
- Pain 13,303
This drug can cause serious harm or death to an unborn baby. Stop taking Zestoretic as soon as you find out you are pregnant.
No specific warnings noted.
Do not take Zestoretic if you are pregnant. It can harm your unborn baby. Talk to your doctor about other blood pressure medicines if you are breastfeeding.
No pregnancy information available.
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How to Read This hydrochlorothiazide/lisinopril vs lisinopril Comparison
hydrochlorothiazide/lisinopril is classified in the Thiazide Diuretic / ACE Inhibitor Combination drug class, while lisinopril sits within the ACE Inhibitor class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, hydrochlorothiazide/lisinopril has 43,279 submissions while lisinopril has 81,066. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to taking these medicines together can cause your blood pressure to drop to an unsafe level, especially when you first start the treatment.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for hydrochlorothiazide/lisinopril or lisinopril.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.