Hydrochlorothiazide/Lisinopril and Hydrochlorothiazide Interaction
Drug interaction information between Hydrochlorothiazide/Lisinopril and Hydrochlorothiazide.
Hydrochlorothiazide/Lisinopril and Hydrochlorothiazide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Hydrochlorothiazide/Lisinopril and Hydrochlorothiazide. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
There are no major negative interactions when these two medicines are used together, and they are often found in the same pill.
What To Do
You can continue taking these medicines together as directed by your healthcare provider.
FDA Label Information
No meaningful clinically important pharmacokinetic interactions occurred when lisinopril was used concomitantly with propranolol, digoxin, or hydrochlorothiazide. Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics. Cholestyramine and colestipol resins - Absorption of hydrochlorothiazide is impaired in the presence of anionic exchange resins.
Hydrochlorothiazide/Lisinopril Also Interacts With
- Aliskiren major
- Lisinopril minor
- Losartan minor
- Spironolactone minor
- Propranolol minor
Hydrochlorothiazide Also Interacts With
- Aliskiren major
- Hydrochlorothiazide/Triamterene major
- Lisinopril major
- Olmesartan moderate
- Losartan minor
Frequently Asked Questions
Can I take Hydrochlorothiazide/Lisinopril and Hydrochlorothiazide together?
This is a minor interaction. You can continue taking these medicines together as directed by your healthcare provider.
How serious is the interaction between Hydrochlorothiazide/Lisinopril and Hydrochlorothiazide?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Hydrochlorothiazide/Lisinopril and Hydrochlorothiazide interact?
There are no major negative interactions when these two medicines are used together, and they are often found in the same pill.
Understanding the Hydrochlorothiazide/Lisinopril and Hydrochlorothiazide Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Hydrochlorothiazide/Lisinopril belongs to the Thiazide Diuretic / ACE Inhibitor Combination class and Hydrochlorothiazide belongs to the Thiazide Diuretic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: There are no major negative interactions when these two medicines are used together, and they are often found in the same pill. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Hydrochlorothiazide/Lisinopril has 13 total documented interactions on file in this dataset, and Hydrochlorothiazide has 31. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: You can continue taking these medicines together as directed by your healthcare provider. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Hydrochlorothiazide/Lisinopril or Hydrochlorothiazide based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.