Hydrochlorothiazide and Hydrochlorothiazide Interaction
Drug interaction information between Hydrochlorothiazide and Hydrochlorothiazide.
Hydrochlorothiazide and Hydrochlorothiazide have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Hydrochlorothiazide and Hydrochlorothiazide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
There are no major negative interactions when these two medicines are used together, and they are often found in the same pill.
FDA Label Information
No meaningful clinically important pharmacokinetic interactions occurred when lisinopril was used concomitantly with propranolol, digoxin, or hydrochlorothiazide. Hydrochlorothiazide When administered concurrently the following drugs may interact with thiazide diuretics. Cholestyramine and colestipol resins - Absorption of hydrochlorothiazide is impaired in the presence of anionic exchange resins.
Hydrochlorothiazide Also Interacts With
- Aliskiren major
- Lisinopril minor
- Losartan minor
- Spironolactone minor
- Propranolol minor
Hydrochlorothiazide Also Interacts With
- Aliskiren major
- Hydrochlorothiazide/Triamterene major
- Lisinopril major
- Olmesartan moderate
- Losartan minor
Frequently Asked Questions
What SPL severity band is on file for Hydrochlorothiazide/Lisinopril + Hydrochlorothiazide?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Hydrochlorothiazide has 31 labeled pairs on file vs Hydrochlorothiazide's 13. In the minor band specifically: Hydrochlorothiazide has 12 (also Lisinopril, Losartan, Spironolactone, Propranolol); Hydrochlorothiazide has 27 (also Losartan, Spironolactone, Propranolol, Lithium).
What mechanism field is on file for Hydrochlorothiazide/Lisinopril and Hydrochlorothiazide?
There are no major negative interactions when these two medicines are used together, and they are often found in the same pill.
Hydrochlorothiazide carries more major-labeled pairs than Hydrochlorothiazide
SPL source-record counts only. This page's band is minor · classes on file: Hydrochlorothiazide (Thiazide Diuretic / ACE Inhibitor Combination); Hydrochlorothiazide (Thiazide Diuretic).
Hydrochlorothiazide has 3 major-labeled pairs vs Hydrochlorothiazide's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 12 minor · 13 total
- Other minor peers for Hydrochlorothiazide
- Lisinopril
- Losartan
- Spironolactone
- Propranolol
3 major · 1 moderate · 27 minor · 31 total
- Other minor peers for Hydrochlorothiazide
- Losartan
- Spironolactone
- Propranolol
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.