Hydrochlorothiazide and Propranolol Interaction
Drug interaction information between Hydrochlorothiazide and Propranolol.
Hydrochlorothiazide and Propranolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Hydrochlorothiazide and Propranolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs do not interfere with how each other is absorbed or processed by the body.
FDA Label Information
No meaningful clinically important pharmacokinetic interactions occurred when lisinopril was used concomitantly with propranolol, digoxin, or hydrochlorothiazide.
Hydrochlorothiazide Also Interacts With
- Aliskiren major
- Lisinopril minor
- Losartan minor
- Hydrochlorothiazide minor
- Spironolactone minor
Frequently Asked Questions
What SPL severity band is on file for Hydrochlorothiazide/Lisinopril + Propranolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Propranolol has 44 labeled pairs on file vs Hydrochlorothiazide's 13. In the minor band specifically: Hydrochlorothiazide has 12 (also Lisinopril, Losartan, Hydrochlorothiazide, Spironolactone); Propranolol has 44 (also Clonidine, Diltiazem, Warfarin, Verapamil).
What mechanism field is on file for Hydrochlorothiazide/Lisinopril and Propranolol?
These drugs do not interfere with how each other is absorbed or processed by the body.
Hydrochlorothiazide carries more major-labeled pairs than Propranolol
SPL source-record counts only. This page's band is minor · classes on file: Hydrochlorothiazide (Thiazide Diuretic / ACE Inhibitor Combination); Propranolol (Non-Selective Beta-Blocker).
Hydrochlorothiazide has 1 major-labeled pair vs Propranolol's 0. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 12 minor · 13 total
- Other minor peers for Hydrochlorothiazide
- Lisinopril
- Losartan
- Hydrochlorothiazide
- Spironolactone
0 major · 0 moderate · 44 minor · 44 total
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.