Hydrochlorothiazide and Aliskiren Interaction
Drug interaction information between Hydrochlorothiazide and Aliskiren.
Hydrochlorothiazide and Aliskiren have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Hydrochlorothiazide and Aliskiren. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Combining these medications puts too much stress on the system that regulates blood pressure, increasing the risk of fainting and kidney damage.
FDA Label Information
Dual Blockade of the Renin-Angiotensin System (RAS) Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. Do not co-administer aliskiren with ZESTORETIC in patients with diabetes. Avoid use of aliskiren with ZESTORETIC in patients with renal impairment (GFR < 60 mL/min).
Hydrochlorothiazide Also Interacts With
- Lisinopril minor
- Losartan minor
- Hydrochlorothiazide minor
- Spironolactone minor
- Propranolol minor
Aliskiren Also Interacts With
- Amlodipine/Benazepril major
- Amlodipine/Valsartan major
- Azilsartan major
- Benazepril major
- Candesartan major
Frequently Asked Questions
What SPL severity band is on file for Hydrochlorothiazide/Lisinopril + Aliskiren?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aliskiren has 28 labeled pairs on file vs Hydrochlorothiazide's 13. In the major band specifically: Hydrochlorothiazide has 1; Aliskiren has 22 (also Amlodipine/Benazepril, Amlodipine/Valsartan, Azilsartan, Benazepril).
What mechanism field is on file for Hydrochlorothiazide/Lisinopril and Aliskiren?
Combining these medications puts too much stress on the system that regulates blood pressure, increasing the risk of fainting and kidney damage.
Aliskiren carries more major-labeled pairs than Hydrochlorothiazide
SPL source-record counts only. This page's band is major · classes on file: Hydrochlorothiazide (Thiazide Diuretic / ACE Inhibitor Combination); Aliskiren (Direct Renin Inhibitor).
Aliskiren has 22 major-labeled pairs vs Hydrochlorothiazide's 1.
1 major · 0 moderate · 12 minor · 13 total
Hydrochlorothiazide has no other major-band peer in this dataset besides Aliskiren.
22 major · 3 moderate · 3 minor · 28 total
- Other major peers for Aliskiren
- Amlodipine/Benazepril
- Amlodipine/Valsartan
- Azilsartan
- Benazepril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.