Hydrochlorothiazide and Amiloride Interaction
Drug interaction information between Hydrochlorothiazide and Amiloride.
Hydrochlorothiazide and Amiloride have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Hydrochlorothiazide and Amiloride. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Amiloride is a medicine that keeps potassium in the body, which can cause potassium levels in your blood to become too high.
FDA Label Information
Use of lisinopril with potassium-sparing diuretics (e.g., spironolactone, eplerenone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes may lead to significant increases in serum potassium.
Hydrochlorothiazide Also Interacts With
- Aliskiren major
- Hydrochlorothiazide/Triamterene major
- Lisinopril major
- Olmesartan moderate
- Losartan minor
Amiloride Also Interacts With
- Potassium Chloride major
- Cyclosporine moderate
- Lithium moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
Frequently Asked Questions
What SPL severity band is on file for Hydrochlorothiazide + Amiloride?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Hydrochlorothiazide has 31 labeled pairs on file vs Amiloride's 19. In the minor band specifically: Hydrochlorothiazide has 27 (also Losartan, Spironolactone, Propranolol, Lithium); Amiloride has 11 (also Indomethacin, Amlodipine/Valsartan, Enalapril, Hydrochlorothiazide).
What mechanism field is on file for Hydrochlorothiazide and Amiloride?
Amiloride is a medicine that keeps potassium in the body, which can cause potassium levels in your blood to become too high.
Hydrochlorothiazide carries more major-labeled pairs than Amiloride
SPL source-record counts only. This page's band is minor · classes on file: Hydrochlorothiazide (Thiazide Diuretic); Amiloride (Potassium-Sparing Diuretic).
Hydrochlorothiazide has 3 major-labeled pairs vs Amiloride's 1. This page itself is in the minor band, not the major band.
3 major · 1 moderate · 27 minor · 31 total
- Other minor peers for Hydrochlorothiazide
- Losartan
- Spironolactone
- Propranolol
- Lithium
1 major · 7 moderate · 11 minor · 19 total
- Other minor peers for Amiloride
- Indomethacin
- Amlodipine/Valsartan
- Enalapril
- Hydrochlorothiazide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.