Hydrochlorothiazide and Lithium Interaction
Drug interaction information between Hydrochlorothiazide and Lithium.
Hydrochlorothiazide and Lithium have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Hydrochlorothiazide and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs cause the body to lose sodium, which can make lithium build up to dangerous levels in your blood.
FDA Label Information
Lithium: Lithium toxicity has been reported in patients receiving lithium concomitantly with drugs which cause elimination of sodium, including ACE inhibitors. Lithium toxicity was usually reversible upon discontinuation of lithium and the ACE inhibitor. It is recommended that serum lithium levels be monitored frequently if lisinopril is administered concomitantly with lithium.
Hydrochlorothiazide Also Interacts With
- Aliskiren major
- Hydrochlorothiazide/Triamterene major
- Lisinopril major
- Olmesartan moderate
- Losartan minor
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Hydrochlorothiazide + Lithium?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Hydrochlorothiazide's 31. In the minor band specifically: Hydrochlorothiazide has 27 (also Losartan, Spironolactone, Propranolol, Amiloride); Lithium has 65 (also Aripiprazole, Asenapine, Canagliflozin, Candesartan).
What mechanism field is on file for Hydrochlorothiazide and Lithium?
These drugs cause the body to lose sodium, which can make lithium build up to dangerous levels in your blood.
Hydrochlorothiazide carries more major-labeled pairs than Lithium
SPL source-record counts only. This page's band is minor · classes on file: Hydrochlorothiazide (Thiazide Diuretic); Lithium (Mood Stabilizer).
Hydrochlorothiazide has 3 major-labeled pairs vs Lithium's 2. This page itself is in the minor band, not the major band.
3 major · 1 moderate · 27 minor · 31 total
- Other minor peers for Hydrochlorothiazide
- Losartan
- Spironolactone
- Propranolol
- Amiloride
2 major · 23 moderate · 65 minor · 90 total
- Other minor peers for Lithium
- Aripiprazole
- Asenapine
- Canagliflozin
- Candesartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.