What the FDA labels say about taking them together
Hydrochlorothiazide and lithium
Hydrochlorothiazide's FDA label of June 12, 2026 names lithium in its warnings section; the lithium labels PlainMeds reads (4) do not name hydrochlorothiazide. The hydrochlorothiazide label: “Cholestyramine and colestipol: Reduced absorption of thiazides Lithium: Increased lithium concentrations and lithium toxicity Antidiabetic drugs:”
Check it at the source: the hydrochlorothiazide FDA label on DailyMed (effective June 12, 2026, Leading Pharma, LLC); the lithium FDA label on DailyMed (effective December 23, 2025, Glenmark Pharmaceuticals Inc., USA).
What does the hydrochlorothiazide label say about lithium?
Hydrochlorothiazide label, warningsLithium generally should not be given with diuretics (see PRECAUTIONS, Drug Interactions ).
Inzirqo label (ANI Pharmaceuticals, Inc., December 16, 2025), drug interactionsCholestyramine and colestipol: Reduced absorption of thiazides (7.1) Lithium: Increased lithium concentrations and lithium toxicity (7.2) Antidiabetic drugs:
Source: FDA drug label (Hydrochlorothiazide, NDA020504), QPharma, Inc., effective December 5, 2025 (SPL set 5bacc909-6b02-4815-85ef-55fd25b1b1f7), via openFDA
Source: FDA drug label (Inzirqo, NDA219141), ANI Pharmaceuticals, Inc., effective December 16, 2025 (SPL set 41aaea48-6c1b-42c8-a96f-5923d49dc934), via openFDA
Source: FDA drug label (HYDROCHLOROTHIAZIDE), Leading Pharma, LLC, effective June 12, 2026 (SPL set 8c868894-667e-4a51-906a-838d63e420ba), via openFDA; the full label on DailyMed
What does the lithium label say about hydrochlorothiazide?
Lithium's label (effective December 23, 2025) and its 3 other brand-application labels do not name hydrochlorothiazide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lithium Carbonate), Glenmark Pharmaceuticals Inc., USA, effective December 23, 2025 (SPL set 63b3790f-a9b5-47f4-bae1-ddf8b43c13c1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Hydrochlorothiazide | Lithium | |
|---|---|---|
| Labeled for | Heart failure, High blood pressure, Edema (fluid retention) | Bipolar disorder |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0115 per tablet 25 mg tablet | $0.104 per capsule 300 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once