Hydrochlorothiazide and Hydrochlorothiazide Interaction
Drug interaction information between Hydrochlorothiazide and Hydrochlorothiazide.
Hydrochlorothiazide and Hydrochlorothiazide have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Hydrochlorothiazide and Hydrochlorothiazide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines can cause your body to lose too much water and salt, which can lead to dehydration or electrolyte imbalances.
FDA Label Information
Monitor blood pressure, renal function, and electrolytes in patients on lisinopril and hydrochlorothiazide tablets and other agents that affect the RAS. Do not coadminister aliskiren with lisinopril and hydrochlorothiazide tablets in patients with diabetes. No meaningful clinically important pharmacokinetic interactions occurred when lisinopril was used concomitantly with propranolol, digoxin, or hydrochlorothiazide.
Hydrochlorothiazide Also Interacts With
- Aliskiren major
- Lisinopril major
- Olmesartan moderate
- Losartan minor
- Spironolactone minor
Hydrochlorothiazide Also Interacts With
- Aliskiren major
- Lisinopril minor
- Losartan minor
- Spironolactone minor
- Propranolol minor
Frequently Asked Questions
What SPL severity band is on file for Hydrochlorothiazide + Hydrochlorothiazide/Triamterene?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Hydrochlorothiazide has 31 labeled pairs on file vs Hydrochlorothiazide's 13. In the major band specifically: Hydrochlorothiazide has 3 (also Aliskiren, Lisinopril); Hydrochlorothiazide has 2 (also Aliskiren).
What mechanism field is on file for Hydrochlorothiazide and Hydrochlorothiazide/Triamterene?
Both of these medicines can cause your body to lose too much water and salt, which can lead to dehydration or electrolyte imbalances.
Hydrochlorothiazide carries more major-labeled pairs than Hydrochlorothiazide
SPL source-record counts only. This page's band is major · classes on file: Hydrochlorothiazide (Thiazide Diuretic); Hydrochlorothiazide (Thiazide / Potassium-Sparing Diuretic Combination).
Hydrochlorothiazide has 3 major-labeled pairs vs Hydrochlorothiazide's 2.
3 major · 1 moderate · 27 minor · 31 total
- Other major peers for Hydrochlorothiazide
- Aliskiren
- Lisinopril
2 major · 0 moderate · 11 minor · 13 total
- Other major peers for Hydrochlorothiazide
- Aliskiren
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.