Haloperidol and Clonidine Interaction
Drug interaction information between Haloperidol and Clonidine.
Haloperidol and Clonidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Haloperidol and Clonidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
High doses of these drugs can cause the heart to beat in an irregular and dangerous way.
FDA Label Information
Based on observations in patients in a state of alcoholic delirium it has been suggested that high intravenous doses of clonidine may increase the arrhythmogenic potential (QT-prolongation, ventricular fibrillation) of high intravenous doses of haloperidol.
Haloperidol Also Interacts With
- Fluoxetine moderate
- Tetrabenazine moderate
- Bromocriptine minor
- Bupropion minor
- Carbamazepine minor
Clonidine Also Interacts With
- Carvedilol moderate
- Metoprolol moderate
- Repaglinide moderate
- Sotalol moderate
- Amitriptyline minor
Frequently Asked Questions
What SPL severity band is on file for Haloperidol + Clonidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clonidine has 29 labeled pairs on file vs Haloperidol's 14. In the minor band specifically: Haloperidol has 12 (also Bromocriptine, Bupropion, Carbamazepine, Clomipramine); Clonidine has 25 (also Amitriptyline, Diltiazem, Verapamil, Amiodarone).
What mechanism field is on file for Haloperidol and Clonidine?
High doses of these drugs can cause the heart to beat in an irregular and dangerous way.
Clonidine's labeled portfolio outnumbers Haloperidol
SPL source-record counts only. This page's band is minor · classes on file: Haloperidol (Typical Antipsychotic); Clonidine (Central Alpha-2 Agonist).
0 major · 2 moderate · 12 minor · 14 total
- Other minor peers for Haloperidol
- Bromocriptine
- Bupropion
- Carbamazepine
- Clomipramine
0 major · 4 moderate · 25 minor · 29 total
- Other minor peers for Clonidine
- Amitriptyline
- Diltiazem
- Verapamil
- Amiodarone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.