Haloperidol and Clomipramine Interaction
Drug interaction information between Haloperidol and Clomipramine.
Haloperidol and Clomipramine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Haloperidol and Clomipramine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Haloperidol can slow down how your body processes clomipramine. This leads to higher amounts of the drug in your blood, which can increase side effects.
FDA Label Information
The plasma concentration of CMI has been reported to be increased by the concomitant administration of haloperidol; plasma levels of several closely related tricyclic antidepressants have been reported to be increased by the concomitant administration of methylphenidate or hepatic enzyme inhibitors (e.g., cimetidine, fluoxetine) and decreased by the concomitant administration of hepatic enzyme inducers (e.g., barbiturates, phenytoin), and such an effect may be anticipated with CMI as well.
Haloperidol Also Interacts With
- Fluoxetine moderate
- Tetrabenazine moderate
- Bromocriptine minor
- Bupropion minor
- Carbamazepine minor
Clomipramine Also Interacts With
- Sertraline minor
- Fluoxetine minor
- Methylphenidate minor
- Paroxetine minor
- Clonidine minor
Frequently Asked Questions
What SPL severity band is on file for Haloperidol + Clomipramine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clomipramine has 15 labeled pairs on file vs Haloperidol's 14. In the minor band specifically: Haloperidol has 12 (also Bromocriptine, Bupropion, Carbamazepine, Clonidine); Clomipramine has 15 (also Sertraline, Fluoxetine, Methylphenidate, Paroxetine).
What mechanism field is on file for Haloperidol and Clomipramine?
Haloperidol can slow down how your body processes clomipramine. This leads to higher amounts of the drug in your blood, which can increase side effects.
Clomipramine's labeled portfolio outnumbers Haloperidol
SPL source-record counts only. This page's band is minor · classes on file: Haloperidol (Typical Antipsychotic); Clomipramine (Tricyclic Antidepressant (TCA)).
0 major · 2 moderate · 12 minor · 14 total
- Other minor peers for Haloperidol
- Bromocriptine
- Bupropion
- Carbamazepine
- Clonidine
0 major · 0 moderate · 15 minor · 15 total
- Other minor peers for Clomipramine
- Sertraline
- Fluoxetine
- Methylphenidate
- Paroxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.