fluconazole vs glimepiride
Side-by-side comparison of fluconazole and glimepiride. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
The following are examples of medications that may increase the glucose-lowering effect of sulfonylureas including glimepiride, increasing the susceptibility to and/or intensity of hypoglycemia: oral anti-diabetic medications, pramlintide acetate, insulin, angiotensin converting enzyme (ACE) inhibitors, H 2 receptor antagonists, fibrates, propoxyphene, pentoxifylline, somatostatin analogs, anabolic steroids and androgens, cyclophosphamide, phenyramidol, guanethidine, fluconazole, sulfinpyrazone, tetracyclines, clarithromycin, disopyramide, quinolones, and those drugs that are highly...
Recommendation: Watch for signs of low blood sugar and consult your doctor about potentially lowering your glimepiride dosage.
Diflucan
Amaryl
Fluconazole is an antifungal medicine. It is used to treat infections caused by fungus.
Glimepiride is a medicine that helps lower blood sugar in adults with type 2 diabetes. It works along with diet and exercise.
Fluconazole treats vaginal yeast infections. It also treats yeast infections in the mouth and esophagus. Fluconazole can also treat urinary tract infections, peritonitis, systemic Candida infections, and pneumonia. It can also treat cryptococcal meningitis. Fluconazole can also prevent candidiasis in patients undergoing bone marrow transplantation.
Glimepiride is used to help control blood sugar levels in adults with type 2 diabetes. It should be used with a healthy diet and regular exercise. This medicine will not work for type 1 diabetes or diabetic ketoacidosis.
Fluconazole works by stopping the growth of fungi. It blocks the fungus from producing a substance it needs to grow. This helps to clear up the infection.
Glimepiride helps your body release more insulin. Insulin helps move sugar from your blood into your cells for energy. This lowers your blood sugar levels.
- • Headache
- • Nausea
- • Abdominal pain
- • Low blood sugar
- • Headache
- • Nausea
- • Dizziness
- Fever 4,121
- Feeling sick to your stomach 3,695
- Loose stools 3,536
- Feeling tired 3,152
- Discomfort 3,121
- High blood sugar 2,972
- Feeling sick to your stomach 2,274
- Loose stools 2,169
- Feeling tired 1,827
- Low blood sugar 1,639
Coadministration of other drugs known to prolong the QT interval and which are metabolized via the enzyme CYP3A4 such as erythromycin, pimozide, and quinidine are contraindicated in patients receiving fluconazole.
Glimepiride can cause low blood sugar, which can be severe. Be careful when driving or operating machinery. If you have an allergic reaction, stop taking glimepiride right away. People with a certain enzyme problem (G6PD deficiency) may get anemia.
Tell your doctor if you are pregnant or plan to become pregnant. Fluconazole may not be safe for your baby. Talk to your doctor about breastfeeding while taking fluconazole.
Tell your doctor if you are pregnant or plan to become pregnant. Glimepiride may not be safe for your baby. It is usually stopped 2 weeks before delivery.
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How to Read This fluconazole vs glimepiride Comparison
fluconazole is classified in the Azole Antifungal drug class, while glimepiride sits within the Sulfonylurea class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, fluconazole has 17,625 submissions while glimepiride has 10,881. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to fluconazole can increase the effect of glimepiride, which makes it more likely for your blood sugar to drop to a dangerously low level.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between fluconazole and glimepiride - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.