Fluvoxamine and Propranolol Interaction
Drug interaction information between Fluvoxamine and Propranolol.
Fluvoxamine and Propranolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Fluvoxamine and Propranolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluvoxamine blocks the liver enzymes that normally break down propranolol. This causes the levels of propranolol in your blood to rise higher than expected.
FDA Label Information
Propranolol or Metoprolol: Reduce dose if coadministered with fluvoxamine and titrate more cautiously ( 7.3 ) . Based on a finding of substantial interactions of fluvoxamine with certain of these drugs (see later parts of this section and also WARNINGS AND PRECAUTIONS [ 5 ] for details) and limited in vitro data for CYP3A4, it appears that fluvoxamine inhibits several cytochrome P450 isoenzymes that are known to be involved in the metabolism of other drugs such as: CYP1A2 (e.g., warfarin, theophylline, propranolol, tizanidine), CYP2C9 (e.g., warfarin), CYP3A4 (e.g., alprazolam), and...
Fluvoxamine Also Interacts With
- Tizanidine major
- Lithium moderate
- Phenelzine moderate
- Tasimelteon moderate
- Metoprolol minor
Frequently Asked Questions
What SPL severity band is on file for Fluvoxamine + Propranolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Propranolol has 44 labeled pairs on file vs Fluvoxamine's 40. In the minor band specifically: Fluvoxamine has 36 (also Metoprolol, Omeprazole, Fluoxetine, Aspirin); Propranolol has 44 (also Clonidine, Diltiazem, Warfarin, Verapamil).
What mechanism field is on file for Fluvoxamine and Propranolol?
Fluvoxamine blocks the liver enzymes that normally break down propranolol. This causes the levels of propranolol in your blood to rise higher than expected.
Fluvoxamine carries more major-labeled pairs than Propranolol
SPL source-record counts only. This page's band is minor · classes on file: Fluvoxamine (Selective Serotonin Reuptake Inhibitor (SSRI)); Propranolol (Non-Selective Beta-Blocker).
Fluvoxamine has 1 major-labeled pair vs Propranolol's 0. This page itself is in the minor band, not the major band.
1 major · 3 moderate · 36 minor · 40 total
- Other minor peers for Fluvoxamine
- Metoprolol
- Omeprazole
- Fluoxetine
- Aspirin
0 major · 0 moderate · 44 minor · 44 total
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.