Fentanyl and Itraconazole Interaction
Drug interaction information between Fentanyl and Itraconazole.
Fentanyl and Itraconazole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Fentanyl and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole prevents your body from breaking down this powerful painkiller. This can cause the drug to reach dangerous levels, which might affect your breathing.
FDA Label Information
Fentanyl Not recommended during and 2 weeks after itraconazole treatment.
Fentanyl Also Interacts With
- Tranylcypromine moderate
- Tramadol minor
- Cyclobenzaprine minor
- Ketoconazole minor
- Diazepam minor
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Fentanyl + Itraconazole?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Fentanyl's 28. In the moderate band specifically: Fentanyl has 2 (also Tranylcypromine); Itraconazole has 20 (also Tamsulosin, Rivaroxaban, Tenofovir Disoproxil, Glecaprevir/Pibrentasvir).
What mechanism field is on file for Fentanyl and Itraconazole?
Itraconazole prevents your body from breaking down this powerful painkiller. This can cause the drug to reach dangerous levels, which might affect your breathing.
Itraconazole carries more major-labeled pairs than Fentanyl
SPL source-record counts only. This page's band is moderate · classes on file: Fentanyl (Opioid Analgesic); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Fentanyl's 0. This page itself is in the moderate band, not the major band.
0 major · 2 moderate · 26 minor · 28 total
- Other moderate peers for Fentanyl
- Tranylcypromine
19 major · 20 moderate · 77 minor · 116 total
- Other moderate peers for Itraconazole
- Tamsulosin
- Rivaroxaban
- Tenofovir Disoproxil
- Glecaprevir/Pibrentasvir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.