Fentanyl and Tranylcypromine Interaction
Drug interaction information between Fentanyl and Tranylcypromine.
Fentanyl and Tranylcypromine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Fentanyl and Tranylcypromine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Combining these drugs can cause a dangerous buildup of serotonin or a sudden, severe spike in blood pressure. This happens because both medications change how your body handles certain brain chemicals.
FDA Label Information
Product Clinical Comment on Concomitant Use [See Contraindications (4.1)] ; Predominant Effect/Risk [Hypertensive Reaction (HR) [See Warnings and Precautions (5.3)] ; or Serotonin Syndrome (SS) [See Warnings and Precautions (5.7)] ] Altretamine Use with caution If not otherwise specified in this table, consider avoiding concomitant use (see also information on medication-free intervals , use agent at the lowest appropriate dose, monitor for effects of the interaction, advise the patient to report potential effects, and be prepared to discontinue the agent and treat effects of the...
Fentanyl Also Interacts With
- Itraconazole moderate
- Tramadol minor
- Cyclobenzaprine minor
- Ketoconazole minor
- Diazepam minor
Tranylcypromine Also Interacts With
- Bupropion major
- Linezolid major
- Vilazodone major
- Epinephrine major
- Norepinephrine major
Frequently Asked Questions
What SPL severity band is on file for Fentanyl + Tranylcypromine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tranylcypromine has 42 labeled pairs on file vs Fentanyl's 28. In the moderate band specifically: Fentanyl has 2 (also Itraconazole); Tranylcypromine has 23 (also Buspirone, Cyclobenzaprine, Carbamazepine, Lithium).
What mechanism field is on file for Fentanyl and Tranylcypromine?
Combining these drugs can cause a dangerous buildup of serotonin or a sudden, severe spike in blood pressure. This happens because both medications change how your body handles certain brain chemicals.
Tranylcypromine carries more major-labeled pairs than Fentanyl
SPL source-record counts only. This page's band is moderate · classes on file: Fentanyl (Opioid Analgesic); Tranylcypromine (Monoamine Oxidase Inhibitor (MAOI)).
Tranylcypromine has 7 major-labeled pairs vs Fentanyl's 0. This page itself is in the moderate band, not the major band.
7 major · 23 moderate · 12 minor · 42 total
- Other moderate peers for Tranylcypromine
- Buspirone
- Cyclobenzaprine
- Carbamazepine
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.