febuxostat vs hydrochlorothiazide
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Side-by-side comparison of febuxostat and hydrochlorothiazide. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7.3 In Vivo Drug Interaction Studies Based on drug interaction studies in healthy patients, febuxostat does not have clinically significant interactions with colchicine, naproxen, indomethacin, hydrochlorothiazide, warfarin or desipramine [see Clinical Pharmacology (12.3) ].
Uloric
Microzide
Febuxostat (Uloric) helps manage high uric acid levels in adults with gout. It is used when allopurinol doesn't work well, causes problems, or isn't a good option.
No summary available.
Febuxostat treats high uric acid levels in adults who have gout. Gout is a type of arthritis that causes sudden, severe pain, swelling, and redness in your joints. This medicine is for people who can't take allopurinol, or for whom allopurinol doesn't work well enough.
Information not available.
Febuxostat lowers uric acid levels in your body. It does this by blocking an enzyme called xanthine oxidase. This enzyme helps make uric acid, so blocking it reduces uric acid production.
Information not available.
- • Abnormal liver function tests
- • Nausea
- • Joint pain
- • Rash
- • Dizziness
- • Headache
- • Cough
- • Fatigue
- Diarrhoea 849
- Nausea 841
- Acute Kidney Injury 837
- Rash 783
- Gout 686
- Fatigue 10,014
- Nausea 9,709
- Diarrhoea 8,311
- Pain 7,663
- Dyspnoea 7,582
Febuxostat may increase the risk of death from heart problems in people with existing heart disease. Talk to your doctor about the risks and benefits of taking febuxostat. Febuxostat should only be used if allopurinol doesn't work well, causes problems, or isn't a good option for you.
No specific warnings noted.
It is not known if febuxostat can harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if febuxostat passes into breast milk. Talk to your doctor about the best way to feed your baby if you are taking this medicine.
No pregnancy information available.
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How to Read This febuxostat vs hydrochlorothiazide Comparison
febuxostat is classified in the Xanthine Oxidase Inhibitor drug class, while hydrochlorothiazide sits within the Thiazide Diuretic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, febuxostat has 3,996 submissions while hydrochlorothiazide has 43,279. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these drugs do not have a meaningful effect on each other when taken at the same time.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for febuxostat or hydrochlorothiazide.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.