Famciclovir and Digoxin Interaction
Drug interaction information between Famciclovir and Digoxin.
Famciclovir and Digoxin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Famciclovir and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medicines do not change each other's levels in the body when they are taken together.
FDA Label Information
(7.2) 7.1 Potential for Famciclovir to Affect Other Drugs The steady-state pharmacokinetics of digoxin were not altered by concomitant administration of multiple doses of famciclovir (500 mg three times daily). No clinically significant effect on penciclovir pharmacokinetics was observed following multiple-dose (three times daily) administration of famciclovir (500 mg) with multiple doses of digoxin.
Famciclovir Also Interacts With
- Allopurinol minor
- Probenecid minor
- Theophylline minor
- Cimetidine minor
- Promethazine minor
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Famciclovir + Digoxin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Famciclovir's 7. In the minor band specifically: Famciclovir has 7 (also Allopurinol, Probenecid, Theophylline, Cimetidine); Digoxin has 105 (also Metformin, Omeprazole, Ibuprofen, Diclofenac).
What mechanism field is on file for Famciclovir and Digoxin?
These medicines do not change each other's levels in the body when they are taken together.
Digoxin carries more major-labeled pairs than Famciclovir
SPL source-record counts only. This page's band is minor · classes on file: Famciclovir (Antiviral (Nucleoside Analog)); Digoxin (Cardiac Glycoside).
Digoxin has 2 major-labeled pairs vs Famciclovir's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 7 minor · 7 total
- Other minor peers for Famciclovir
- Allopurinol
- Probenecid
- Theophylline
- Cimetidine
2 major · 13 moderate · 105 minor · 120 total
- Other minor peers for Digoxin
- Metformin
- Omeprazole
- Ibuprofen
- Diclofenac
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.