digoxin vs famciclovir

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Side-by-side comparison of digoxin and famciclovir. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.

minor Known Drug Interaction

(7.2) 7.1 Potential for Famciclovir to Affect Other Drugs The steady-state pharmacokinetics of digoxin were not altered by concomitant administration of multiple doses of famciclovir (500 mg three times daily). No clinically significant effect on penciclovir pharmacokinetics was observed following multiple-dose (three times daily) administration of famciclovir (500 mg) with multiple doses of digoxin.

Drug Class
digoxin Cardiac Glycoside
famciclovir Antiviral (Nucleoside Analog)
Type
digoxin Prescription
famciclovir Prescription
Summary
digoxin

Digoxin (Lanoxin) is a medicine that helps your heart pump better. It is used to treat heart failure and control irregular heartbeats.

famciclovir

Famciclovir is an antiviral medicine. It helps to treat infections caused by certain viruses.

What It Treats
digoxin

Digoxin is used to treat mild to moderate heart failure in adults. It helps the heart pump more blood with each beat. Digoxin is also used in children with heart failure to help their heart work better. In adults, it can control a fast and irregular heartbeat called atrial fibrillation.

famciclovir

This medicine treats herpes infections. It can treat cold sores, genital herpes, and shingles. It can also prevent genital herpes outbreaks. This medicine may not work for everyone, including first-time genital herpes, eye shingles, or certain immunocompromised patients.

How It Works
digoxin

Digoxin belongs to a class of drugs called cardiac glycosides. It works by making the heart muscle contract more strongly. It also slows down the electrical signals in the heart, which can help control irregular heartbeats.

famciclovir

Famciclovir stops the virus from multiplying. It does this by blocking a key enzyme the virus needs to make copies of itself. This helps your body fight off the infection.

Common Side Effects
digoxin
  • Nausea
  • Vomiting
  • Diarrhea
  • Dizziness
  • Headache
famciclovir
  • Headache
  • Nausea
FAERS Reports
digoxin
  • Dyspnoea 6,065
  • Nausea 4,754
  • Dizziness 4,439
  • Fatigue 4,175
  • Atrial Fibrillation 3,974
famciclovir
  • Fatigue 185
  • Diarrhoea 179
  • Nausea 145
  • Headache 135
  • Pain 118
Serious Warnings
digoxin

Digoxin can cause serious side effects, including dangerous heart rhythms. You are at higher risk if you have certain heart conditions or kidney problems. Tell your doctor right away if you have nausea, vomiting, vision changes, or an irregular heartbeat.

famciclovir

If you have kidney problems, make sure your doctor knows. Taking too much famciclovir when you have kidney problems can damage your kidneys.

Pregnancy
digoxin

It is not known if digoxin can harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. The medicine passes into breast milk, but it is unlikely to harm the baby.

famciclovir

Tell your doctor if you are pregnant or plan to become pregnant. Untreated herpes during pregnancy can harm the baby. It is not known if famciclovir passes into breast milk.

Also Compare, Nearby Drugs

How to Read This digoxin vs famciclovir Comparison

digoxin is classified in the Cardiac Glycoside drug class, while famciclovir sits within the Antiviral (Nucleoside Analog) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.

Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, digoxin has 23,407 submissions while famciclovir has 762. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these medicines do not change each other's levels in the body when they are taken together.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.

A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for digoxin or famciclovir.

Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.