Famciclovir and Probenecid Interaction
Drug interaction information between Famciclovir and Probenecid.
Famciclovir and Probenecid have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Famciclovir and Probenecid. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Probenecid stops the kidneys from clearing the other medicine out of your system as quickly as usual.
FDA Label Information
7 DRUG INTERACTIONS Probenecid: May increase penciclovir levels. Concurrent use with probenecid or other drugs significantly eliminated by active renal tubular secretion may result in increased plasma concentrations of penciclovir.
Famciclovir Also Interacts With
- Allopurinol minor
- Digoxin minor
- Theophylline minor
- Cimetidine minor
- Promethazine minor
Probenecid Also Interacts With
- Ketorolac major
- Levofloxacin major
- Amoxicillin moderate
- Amoxicillin/Clavulanate moderate
- Ceftazidime/Avibactam moderate
Frequently Asked Questions
What SPL severity band is on file for Famciclovir + Probenecid?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Probenecid has 37 labeled pairs on file vs Famciclovir's 7. In the minor band specifically: Famciclovir has 7 (also Allopurinol, Digoxin, Theophylline, Cimetidine); Probenecid has 23 (also Theophylline, Acetaminophen/Oxycodone, Ampicillin/Sulbactam, Carbidopa/Levodopa).
What mechanism field is on file for Famciclovir and Probenecid?
Probenecid stops the kidneys from clearing the other medicine out of your system as quickly as usual.
Probenecid carries more major-labeled pairs than Famciclovir
SPL source-record counts only. This page's band is minor · classes on file: Famciclovir (Antiviral (Nucleoside Analog)); Probenecid (Uricosuric Agent).
Probenecid has 2 major-labeled pairs vs Famciclovir's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 7 minor · 7 total
- Other minor peers for Famciclovir
- Allopurinol
- Digoxin
- Theophylline
- Cimetidine
2 major · 12 moderate · 23 minor · 37 total
- Other minor peers for Probenecid
- Theophylline
- Acetaminophen/Oxycodone
- Ampicillin/Sulbactam
- Carbidopa/Levodopa
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.