Diltiazem and Digoxin Interaction
Drug interaction information between Diltiazem and Digoxin.
Diltiazem and Digoxin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Diltiazem and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Diltiazem can cause the amount of digoxin in your blood to rise, which may lead to side effects from having too much medicine in your system.
FDA Label Information
Digitalis : Administration of diltiazem hydrochloride with digoxin in 24 healthy male subjects increased plasma digoxin concentrations approximately 20%. Another investigator found no increase in digoxin levels in 12 patients with coronary artery disease. Monitor digoxin levels when initiating, adjusting, and discontinuing diltiazem hydrochloride therapy to avoid possible over- or under- digitalization (see WARNINGS ).
Diltiazem Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Theophylline major
- Rifampin moderate
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Diltiazem + Digoxin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Diltiazem's 46. In the moderate band specifically: Diltiazem has 7 (also Rifampin, Ivabradine, Aprepitant, Metoprolol); Digoxin has 13 (also Sotalol, Dofetilide, Ivabradine, Dopamine).
What mechanism field is on file for Diltiazem and Digoxin?
Diltiazem can cause the amount of digoxin in your blood to rise, which may lead to side effects from having too much medicine in your system.
Diltiazem carries more major-labeled pairs than Digoxin
SPL source-record counts only. This page's band is moderate · classes on file: Diltiazem (Calcium Channel Blocker); Digoxin (Cardiac Glycoside).
Diltiazem has 4 major-labeled pairs vs Digoxin's 2. This page itself is in the moderate band, not the major band.
4 major · 7 moderate · 35 minor · 46 total
- Other moderate peers for Diltiazem
- Rifampin
- Ivabradine
- Aprepitant
- Metoprolol
2 major · 13 moderate · 105 minor · 120 total
- Other moderate peers for Digoxin
- Sotalol
- Dofetilide
- Ivabradine
- Dopamine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.