Doxycycline and Doxycycline Hyclate Interaction
Drug interaction information between Doxycycline and Doxycycline Hyclate.
Doxycycline and Doxycycline Hyclate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Doxycycline and Doxycycline Hyclate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Certain medications can cause your body to clear doxycycline from your system much faster than usual.
FDA Label Information
Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline.
Doxycycline Also Interacts With
- Tetracycline moderate
- Rifampin moderate
- Carbamazepine minor
- Bismuth Subsalicylate minor
- Phenytoin minor
Doxycycline Hyclate Also Interacts With
- Tetracycline moderate
- Carbamazepine minor
- Bismuth Subsalicylate minor
- Phenytoin minor
Frequently Asked Questions
What SPL severity band is on file for Doxycycline + Doxycycline Hyclate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Doxycycline has 9 labeled pairs on file vs Doxycycline Hyclate's 5. In the minor band specifically: Doxycycline has 7 (also Carbamazepine, Bismuth Subsalicylate, Phenytoin, Ethinyl Estradiol); Doxycycline Hyclate has 4 (also Carbamazepine, Bismuth Subsalicylate, Phenytoin).
What mechanism field is on file for Doxycycline and Doxycycline Hyclate?
Certain medications can cause your body to clear doxycycline from your system much faster than usual.
Doxycycline's labeled portfolio outnumbers Doxycycline Hyclate
SPL source-record counts only. This page's band is minor · classes on file: Doxycycline (Tetracycline Antibiotic); Doxycycline Hyclate (Tetracycline Antibiotic (Antimalarial)).
0 major · 2 moderate · 7 minor · 9 total
- Other minor peers for Doxycycline
- Carbamazepine
- Bismuth Subsalicylate
- Phenytoin
- Ethinyl Estradiol
0 major · 1 moderate · 4 minor · 5 total
- Other minor peers for Doxycycline Hyclate
- Carbamazepine
- Bismuth Subsalicylate
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.