Ethinyl Estradiol and Estradiol Interaction
Drug interaction information between Ethinyl Estradiol and Estradiol.
Ethinyl Estradiol and Estradiol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ethinyl Estradiol and Estradiol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Colesevelam can trap the birth control hormones in your gut and stop them from being absorbed into your body. This can make your birth control less effective at preventing pregnancy.
FDA Label Information
No drug-drug interaction studies were conducted with levonorgestrel and ethinyl estradiol tablets. ( 7.1 ) 7.1 Effects of Other Drugs on Combined Oral Contraceptives Substances decreasing the plasma concentrations of COCs and potentially diminishing the efficacy of COCs: Table 5 includes substances that demonstrated an important drug interaction with levonorgestrel and ethinyl estradiol tablets. Colesevelam Clinical effect Concomitant use of COCs with colesevelam significantly decreases systemic exposure of ethinyl estradiol [see Clinical Pharmacology (12.3) ] .
Ethinyl Estradiol Also Interacts With
- Glecaprevir/Pibrentasvir moderate
- Atorvastatin minor
- Rosuvastatin minor
- Lamotrigine minor
- Topiramate minor
Estradiol Also Interacts With
- Drospirenone/Ethinyl Estradiol major
- Glecaprevir/Pibrentasvir moderate
- Etonogestrel moderate
- Tacrolimus Topical moderate
- Rosuvastatin minor
Frequently Asked Questions
What SPL severity band is on file for Ethinyl Estradiol/Norgestimate + Estradiol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Estradiol has 54 labeled pairs on file vs Ethinyl Estradiol's 30. In the minor band specifically: Ethinyl Estradiol has 29 (also Atorvastatin, Rosuvastatin, Lamotrigine, Topiramate); Estradiol has 50 (also Rosuvastatin, Lamotrigine, Topiramate, Tizanidine).
What mechanism field is on file for Ethinyl Estradiol/Norgestimate and Estradiol?
Colesevelam can trap the birth control hormones in your gut and stop them from being absorbed into your body. This can make your birth control less effective at preventing pregnancy.
Estradiol carries more major-labeled pairs than Ethinyl Estradiol
SPL source-record counts only. This page's band is minor · classes on file: Ethinyl Estradiol (Combined Oral Contraceptive); Estradiol (Estrogen Hormone).
Estradiol has 1 major-labeled pair vs Ethinyl Estradiol's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 29 minor · 30 total
- Other minor peers for Ethinyl Estradiol
- Atorvastatin
- Rosuvastatin
- Lamotrigine
- Topiramate
1 major · 3 moderate · 50 minor · 54 total
- Other minor peers for Estradiol
- Rosuvastatin
- Lamotrigine
- Topiramate
- Tizanidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.