What the FDA labels say about taking them together
Ethinyl estradiol/norgestimate and lamotrigine
Ethinyl estradiol/norgestimate's FDA label of February 6, 2026 names lamotrigine in its drug interactions section; the lamotrigine labels PlainMeds reads (3) do not name ethinyl estradiol/norgestimate. The ethinyl estradiol/norgestimate label: “COCs have been shown to decrease plasma concentrations of acetaminophen, clofibric acid, morphine, salicylic acid, temazepam and lamotrigine.”
Check it at the source: the ethinyl estradiol/norgestimate FDA label on DailyMed (effective February 6, 2026, Glenmark Pharmaceuticals Inc., USA); the lamotrigine FDA label on DailyMed (effective October 10, 2025).
What does the ethinyl estradiol/norgestimate label say about lamotrigine?
Ethinyl estradiol/norgestimate label, drug interactionsCOCs have been shown to decrease plasma concentrations of acetaminophen, clofibric acid, morphine, salicylic acid, temazepam and lamotrigine.
Source: FDA drug label (Norgestimate and Ethinyl Estradiol), Glenmark Pharmaceuticals Inc., USA, effective February 6, 2026 (SPL set 8b247e46-203e-4f5b-b5a7-cbd57341c735), via openFDA; the full label on DailyMed
What does the lamotrigine label say about ethinyl estradiol/norgestimate?
Lamotrigine's label (effective October 10, 2025) and its 2 other brand-application labels do not name ethinyl estradiol/norgestimate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LAMICTAL), GlaxoSmithKline LLC, effective October 10, 2025 (SPL set d7e3572d-56fe-4727-2bb4-013ccca22678), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ethinyl estradiol/norgestimate | Lamotrigine | |
|---|---|---|
| Labeled for | Acne, Birth control | Seizures and epilepsy, Bipolar disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.115 per tablet 0.25-0.035 mg tablet | $0.0268 per tablet 25 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once