Ethinyl Estradiol and Rosuvastatin Interaction
Drug interaction information between Ethinyl Estradiol and Rosuvastatin.
Ethinyl Estradiol and Rosuvastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ethinyl Estradiol and Rosuvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rosuvastatin increases the amount of birth control hormone that stays in your blood. This happens because the statin changes how your body processes the hormone.
FDA Label Information
Substances increasing the systemic exposure of COCs: Co-administration of atorvastatin or rosuvastatin and certain COCs containing ethinyl estradiol (EE) increase AUC values for EE by approximately 20 to 25%.
Ethinyl Estradiol Also Interacts With
- Glecaprevir/Pibrentasvir moderate
- Atorvastatin minor
- Estradiol minor
- Lamotrigine minor
- Topiramate minor
Rosuvastatin Also Interacts With
- Sofosbuvir/Velpatasvir major
- Glecaprevir/Pibrentasvir major
- Febuxostat major
- Cyclosporine moderate
- Ledipasvir/Sofosbuvir moderate
Frequently Asked Questions
What SPL severity band is on file for Ethinyl Estradiol/Norgestimate + Rosuvastatin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ethinyl Estradiol has 30 labeled pairs on file vs Rosuvastatin's 21. In the minor band specifically: Ethinyl Estradiol has 29 (also Atorvastatin, Estradiol, Lamotrigine, Topiramate); Rosuvastatin has 10 (also Fenofibrate, Warfarin, Brexpiprazole, Darunavir).
What mechanism field is on file for Ethinyl Estradiol/Norgestimate and Rosuvastatin?
Rosuvastatin increases the amount of birth control hormone that stays in your blood. This happens because the statin changes how your body processes the hormone.
Rosuvastatin carries more major-labeled pairs than Ethinyl Estradiol
SPL source-record counts only. This page's band is minor · classes on file: Ethinyl Estradiol (Combined Oral Contraceptive); Rosuvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Rosuvastatin has 3 major-labeled pairs vs Ethinyl Estradiol's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 29 minor · 30 total
- Other minor peers for Ethinyl Estradiol
- Atorvastatin
- Estradiol
- Lamotrigine
- Topiramate
3 major · 8 moderate · 10 minor · 21 total
- Other minor peers for Rosuvastatin
- Fenofibrate
- Warfarin
- Brexpiprazole
- Darunavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.