Ethinyl Estradiol and Topiramate Interaction
Drug interaction information between Ethinyl Estradiol and Topiramate.
Ethinyl Estradiol and Topiramate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ethinyl Estradiol and Topiramate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Topiramate speeds up the way your liver removes birth control hormones from your system. This can lower the level of the medicine in your body and make it less likely to prevent pregnancy.
FDA Label Information
Examples Aprepitant, barbiturates, bosentan, carbamazepine, efavirenz, felbamate, griseofulvin, oxcarbazepine, phenytoin, rifampin, rifabutin, rufinamide, topiramate, products containing St.
Ethinyl Estradiol Also Interacts With
- Glecaprevir/Pibrentasvir moderate
- Atorvastatin minor
- Rosuvastatin minor
- Estradiol minor
- Lamotrigine minor
Topiramate Also Interacts With
- Zonisamide moderate
- Alogliptin moderate
- Ertugliflozin moderate
- Hydrochlorothiazide minor
- Amitriptyline minor
Frequently Asked Questions
What SPL severity band is on file for Ethinyl Estradiol/Norgestimate + Topiramate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
How many labeled pairs sit in each drug's minor band?
Ethinyl Estradiol and Topiramate tie at 30 labeled pairs each. minor-band counts: Ethinyl Estradiol 29 alongside Atorvastatin, Rosuvastatin, Estradiol, Lamotrigine; Topiramate 27 alongside Hydrochlorothiazide, Amitriptyline, Pioglitazone, Carbamazepine.
What mechanism field is on file for Ethinyl Estradiol/Norgestimate and Topiramate?
Topiramate speeds up the way your liver removes birth control hormones from your system. This can lower the level of the medicine in your body and make it less likely to prevent pregnancy.
Ethinyl Estradiol and Topiramate · minor-band peers
SPL source-record counts only. This page's band is minor · classes on file: Ethinyl Estradiol (Combined Oral Contraceptive); Topiramate (Anticonvulsant).
0 major · 1 moderate · 29 minor · 30 total
- Other minor peers for Ethinyl Estradiol
- Atorvastatin
- Rosuvastatin
- Estradiol
- Lamotrigine
0 major · 3 moderate · 27 minor · 30 total
- Other minor peers for Topiramate
- Hydrochlorothiazide
- Amitriptyline
- Pioglitazone
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.