Ethinyl Estradiol and Estradiol Interaction
Drug interaction information between Ethinyl Estradiol and Estradiol.
Ethinyl Estradiol and Estradiol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ethinyl Estradiol and Estradiol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
The estrogen in your birth control can slow down how your body processes other estrogen medicines. This can cause the hormone levels to build up in your system.
FDA Label Information
7.2 Increase in Plasma Levels of Estradiol Associated with Co-Administered Drugs Co-administration of atorvastatin and certain COCs containing ethinyl estradiol increase AUC values for ethinyl estradiol by approximately 20%. Ascorbic acid and acetaminophen may increase plasma ethinyl estradiol levels, possibly by inhibition of conjugation. 7.4 Changes in Plasma Levels of Co-Administered Drugs COCs containing some synthetic estrogens (e.g., ethinyl estradiol) may inhibit the metabolism of other compounds.
Ethinyl Estradiol Also Interacts With
- Atorvastatin minor
- Lamotrigine minor
- Topiramate minor
- Acetaminophen minor
- Ketoconazole minor
Estradiol Also Interacts With
- Drospirenone/Ethinyl Estradiol major
- Glecaprevir/Pibrentasvir moderate
- Etonogestrel moderate
- Tacrolimus Topical moderate
- Rosuvastatin minor
Frequently Asked Questions
What SPL severity band is on file for Ethinyl Estradiol/Levonorgestrel + Estradiol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Estradiol has 54 labeled pairs on file vs Ethinyl Estradiol's 14. In the minor band specifically: Ethinyl Estradiol has 14 (also Atorvastatin, Lamotrigine, Topiramate, Acetaminophen); Estradiol has 50 (also Rosuvastatin, Lamotrigine, Topiramate, Tizanidine).
What mechanism field is on file for Ethinyl Estradiol/Levonorgestrel and Estradiol?
The estrogen in your birth control can slow down how your body processes other estrogen medicines. This can cause the hormone levels to build up in your system.
Estradiol carries more major-labeled pairs than Ethinyl Estradiol
SPL source-record counts only. This page's band is minor · classes on file: Ethinyl Estradiol (Combined Oral Contraceptive); Estradiol (Estrogen Hormone).
Estradiol has 1 major-labeled pair vs Ethinyl Estradiol's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 14 minor · 14 total
- Other minor peers for Ethinyl Estradiol
- Atorvastatin
- Lamotrigine
- Topiramate
- Acetaminophen
1 major · 3 moderate · 50 minor · 54 total
- Other minor peers for Estradiol
- Rosuvastatin
- Lamotrigine
- Topiramate
- Tizanidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.