Ethinyl Estradiol and Atorvastatin Interaction
Drug interaction information between Ethinyl Estradiol and Atorvastatin.
Ethinyl Estradiol and Atorvastatin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ethinyl Estradiol and Atorvastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This cholesterol medicine can increase the amount of estrogen from your birth control that stays in your body. It changes how your body processes the hormone.
FDA Label Information
7.2 Increase in Plasma Levels of Estradiol Associated with Co-Administered Drugs Co-administration of atorvastatin and certain COCs containing ethinyl estradiol increase AUC values for ethinyl estradiol by approximately 20%.
Ethinyl Estradiol Also Interacts With
- Estradiol minor
- Lamotrigine minor
- Topiramate minor
- Acetaminophen minor
- Ketoconazole minor
Atorvastatin Also Interacts With
- Clarithromycin major
- Darunavir major
- Itraconazole major
- Cyclosporine moderate
- Colchicine moderate
Frequently Asked Questions
What SPL severity band is on file for Ethinyl Estradiol/Levonorgestrel + Atorvastatin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Atorvastatin has 36 labeled pairs on file vs Ethinyl Estradiol's 14. In the minor band specifically: Ethinyl Estradiol has 14 (also Estradiol, Lamotrigine, Topiramate, Acetaminophen); Atorvastatin has 25 (also Estradiol, Norethindrone, Ketoconazole, Erythromycin).
What mechanism field is on file for Ethinyl Estradiol/Levonorgestrel and Atorvastatin?
This cholesterol medicine can increase the amount of estrogen from your birth control that stays in your body. It changes how your body processes the hormone.
Atorvastatin carries more major-labeled pairs than Ethinyl Estradiol
SPL source-record counts only. This page's band is minor · classes on file: Ethinyl Estradiol (Combined Oral Contraceptive); Atorvastatin (HMG-CoA Reductase Inhibitor (Statin)).
Atorvastatin has 3 major-labeled pairs vs Ethinyl Estradiol's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 14 minor · 14 total
- Other minor peers for Ethinyl Estradiol
- Estradiol
- Lamotrigine
- Topiramate
- Acetaminophen
3 major · 8 moderate · 25 minor · 36 total
- Other minor peers for Atorvastatin
- Estradiol
- Norethindrone
- Ketoconazole
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.