Ethinyl Estradiol and Lamotrigine Interaction
Drug interaction information between Ethinyl Estradiol and Lamotrigine.
Ethinyl Estradiol and Lamotrigine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ethinyl Estradiol and Lamotrigine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Birth control pills can make your body get rid of this seizure medicine too quickly. This can lower the amount of medicine in your blood and might cause a seizure.
FDA Label Information
COCs have been shown to significantly decrease plasma concentrations of lamotrigine likely due to induction of lamotrigine glucuronidation. This may reduce seizure control; therefore, dosage adjustments of lamotrigine may be necessary.
Ethinyl Estradiol Also Interacts With
- Atorvastatin minor
- Estradiol minor
- Topiramate minor
- Acetaminophen minor
- Ketoconazole minor
Lamotrigine Also Interacts With
- Dofetilide moderate
- Desmopressin moderate
- Valproate minor
- Carbamazepine minor
- Rifampin minor
Frequently Asked Questions
What SPL severity band is on file for Ethinyl Estradiol/Levonorgestrel + Lamotrigine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lamotrigine has 24 labeled pairs on file vs Ethinyl Estradiol's 14. In the minor band specifically: Ethinyl Estradiol has 14 (also Atorvastatin, Estradiol, Topiramate, Acetaminophen); Lamotrigine has 22 (also Valproate, Carbamazepine, Rifampin, Phenytoin).
What mechanism field is on file for Ethinyl Estradiol/Levonorgestrel and Lamotrigine?
Birth control pills can make your body get rid of this seizure medicine too quickly. This can lower the amount of medicine in your blood and might cause a seizure.
Lamotrigine's labeled portfolio outnumbers Ethinyl Estradiol
SPL source-record counts only. This page's band is minor · classes on file: Ethinyl Estradiol (Combined Oral Contraceptive); Lamotrigine (Anticonvulsant).
0 major · 0 moderate · 14 minor · 14 total
- Other minor peers for Ethinyl Estradiol
- Atorvastatin
- Estradiol
- Topiramate
- Acetaminophen
0 major · 2 moderate · 22 minor · 24 total
- Other minor peers for Lamotrigine
- Valproate
- Carbamazepine
- Rifampin
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.