Ethinyl Estradiol and Acetaminophen Interaction
Drug interaction information between Ethinyl Estradiol and Acetaminophen.
Ethinyl Estradiol and Acetaminophen have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ethinyl Estradiol and Acetaminophen. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Acetaminophen stops the body from processing the estrogen in the birth control pill. This leads to higher levels of the hormone in your blood.
FDA Label Information
Ascorbic acid and acetaminophen may increase plasma ethinyl estradiol levels, possibly by inhibition of conjugation.
Ethinyl Estradiol Also Interacts With
- Atorvastatin minor
- Estradiol minor
- Lamotrigine minor
- Topiramate minor
- Ketoconazole minor
Acetaminophen Also Interacts With
- Dapsone Topical moderate
- Lidocaine Topical moderate
- Acetaminophen/Oxycodone minor
- Carbamazepine minor
- Cidofovir minor
Frequently Asked Questions
What SPL severity band is on file for Ethinyl Estradiol/Levonorgestrel + Acetaminophen?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Acetaminophen has 23 labeled pairs on file vs Ethinyl Estradiol's 14. In the minor band specifically: Ethinyl Estradiol has 14 (also Atorvastatin, Estradiol, Lamotrigine, Topiramate); Acetaminophen has 21 (also Acetaminophen/Oxycodone, Carbamazepine, Cidofovir, Codeine).
What mechanism field is on file for Ethinyl Estradiol/Levonorgestrel and Acetaminophen?
Acetaminophen stops the body from processing the estrogen in the birth control pill. This leads to higher levels of the hormone in your blood.
Acetaminophen's labeled portfolio outnumbers Ethinyl Estradiol
SPL source-record counts only. This page's band is minor · classes on file: Ethinyl Estradiol (Combined Oral Contraceptive); Acetaminophen (Analgesic / Antipyretic).
0 major · 0 moderate · 14 minor · 14 total
- Other minor peers for Ethinyl Estradiol
- Atorvastatin
- Estradiol
- Lamotrigine
- Topiramate
0 major · 2 moderate · 21 minor · 23 total
- Other minor peers for Acetaminophen
- Acetaminophen/Oxycodone
- Carbamazepine
- Cidofovir
- Codeine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.