Ethinyl Estradiol and Ketoconazole Interaction
Drug interaction information between Ethinyl Estradiol and Ketoconazole.
Ethinyl Estradiol and Ketoconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Ethinyl Estradiol and Ketoconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ketoconazole blocks a specific liver enzyme that normally clears birth control hormones from your body. This leads to higher levels of the hormones in your system.
FDA Label Information
CYP3A4 inhibitors such as itraconazole or ketoconazole may increase plasma hormone levels.
Ethinyl Estradiol Also Interacts With
- Atorvastatin minor
- Estradiol minor
- Lamotrigine minor
- Topiramate minor
- Acetaminophen minor
Ketoconazole Also Interacts With
- Alfuzosin major
- Dronedarone major
- Ranolazine major
- Saxagliptin major
- Sildenafil major
Frequently Asked Questions
What SPL severity band is on file for Ethinyl Estradiol/Levonorgestrel + Ketoconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ketoconazole has 113 labeled pairs on file vs Ethinyl Estradiol's 14. In the minor band specifically: Ethinyl Estradiol has 14 (also Atorvastatin, Estradiol, Lamotrigine, Topiramate); Ketoconazole has 85 (also Abiraterone, Acetaminophen/Oxycodone, Alosetron, Amphotericin B).
What mechanism field is on file for Ethinyl Estradiol/Levonorgestrel and Ketoconazole?
Ketoconazole blocks a specific liver enzyme that normally clears birth control hormones from your body. This leads to higher levels of the hormones in your system.
Ketoconazole carries more major-labeled pairs than Ethinyl Estradiol
SPL source-record counts only. This page's band is minor · classes on file: Ethinyl Estradiol (Combined Oral Contraceptive); Ketoconazole (Azole Antifungal).
Ketoconazole has 6 major-labeled pairs vs Ethinyl Estradiol's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 14 minor · 14 total
- Other minor peers for Ethinyl Estradiol
- Atorvastatin
- Estradiol
- Lamotrigine
- Topiramate
6 major · 22 moderate · 85 minor · 113 total
- Other minor peers for Ketoconazole
- Abiraterone
- Acetaminophen/Oxycodone
- Alosetron
- Amphotericin B
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.