Estradiol and Acetaminophen Interaction
Drug interaction information between Estradiol and Acetaminophen.
Estradiol and Acetaminophen have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Estradiol and Acetaminophen. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs can change how the other is processed, which may raise hormone levels and lower the amount of pain medicine in your blood. This could make your pain reliever less effective.
FDA Label Information
Ascorbic acid and acetaminophen may increase systemic exposure of EE possibly by inhibition of conjugation. Other Drugs Clinical effect Concomitant use of COCs may decrease systemic exposure of acetaminophen, morphine, salicylic acid, and temazepam.
Estradiol Also Interacts With
- Drospirenone/Ethinyl Estradiol major
- Glecaprevir/Pibrentasvir moderate
- Etonogestrel moderate
- Tacrolimus Topical moderate
- Rosuvastatin minor
Acetaminophen Also Interacts With
- Dapsone Topical moderate
- Lidocaine Topical moderate
- Acetaminophen/Oxycodone minor
- Carbamazepine minor
- Cidofovir minor
Frequently Asked Questions
What SPL severity band is on file for Estradiol + Acetaminophen?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Estradiol has 54 labeled pairs on file vs Acetaminophen's 23. In the minor band specifically: Estradiol has 50 (also Rosuvastatin, Lamotrigine, Topiramate, Tizanidine); Acetaminophen has 21 (also Acetaminophen/Oxycodone, Carbamazepine, Cidofovir, Codeine).
What mechanism field is on file for Estradiol and Acetaminophen?
These two drugs can change how the other is processed, which may raise hormone levels and lower the amount of pain medicine in your blood. This could make your pain reliever less effective.
Estradiol carries more major-labeled pairs than Acetaminophen
SPL source-record counts only. This page's band is minor · classes on file: Estradiol (Estrogen Hormone); Acetaminophen (Analgesic / Antipyretic).
Estradiol has 1 major-labeled pair vs Acetaminophen's 0. This page itself is in the minor band, not the major band.
1 major · 3 moderate · 50 minor · 54 total
- Other minor peers for Estradiol
- Rosuvastatin
- Lamotrigine
- Topiramate
- Tizanidine
0 major · 2 moderate · 21 minor · 23 total
- Other minor peers for Acetaminophen
- Acetaminophen/Oxycodone
- Carbamazepine
- Cidofovir
- Codeine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.