Epinephrine and Clonidine Interaction
Drug interaction information between Epinephrine and Clonidine.
Epinephrine and Clonidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Epinephrine and Clonidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clonidine can increase the way epinephrine affects your blood pressure and heart. This makes the epinephrine more powerful and could lead to an unexpected reaction.
FDA Label Information
( 7 .1) Drugs that potentiate the effects of epinephrine include sympathomimetics, beta blockers, tricyclic antidepressants, MAO inhibitors, COMT inhibitors, clonidine, doxapram, oxytocin, levothyroxine sodium, and certain antihistamines. ( 7 .4) 7.1 Drugs Antagonizing Pressor Effects of Epinephrine • α-blockers, such as phentolamine • Vasodilators, such as nitrates • Diuretics • Antihypertensives • Ergot alkaloids • Phenothiazine antipsychotics 7.2 Drugs Potentiating Pressor Effects of Epinephrine • Sympathomimetics • β-blockers, such as propranolol • Tricyclic anti-depressants •...
Epinephrine Also Interacts With
- Tranylcypromine major
- Carbidopa/Levodopa moderate
- Digoxin moderate
- Imipramine moderate
- Levothyroxine minor
Clonidine Also Interacts With
- Carvedilol moderate
- Metoprolol moderate
- Repaglinide moderate
- Sotalol moderate
- Amitriptyline minor
Frequently Asked Questions
What SPL severity band is on file for Epinephrine + Clonidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clonidine has 29 labeled pairs on file vs Epinephrine's 28. In the minor band specifically: Epinephrine has 24 (also Levothyroxine, Theophylline, Oxytocin, Amitriptyline); Clonidine has 25 (also Amitriptyline, Diltiazem, Verapamil, Haloperidol).
What mechanism field is on file for Epinephrine and Clonidine?
Clonidine can increase the way epinephrine affects your blood pressure and heart. This makes the epinephrine more powerful and could lead to an unexpected reaction.
Epinephrine carries more major-labeled pairs than Clonidine
SPL source-record counts only. This page's band is minor · classes on file: Epinephrine (Adrenergic Agonist); Clonidine (Central Alpha-2 Agonist).
Epinephrine has 1 major-labeled pair vs Clonidine's 0. This page itself is in the minor band, not the major band.
1 major · 3 moderate · 24 minor · 28 total
- Other minor peers for Epinephrine
- Levothyroxine
- Theophylline
- Oxytocin
- Amitriptyline
0 major · 4 moderate · 25 minor · 29 total
- Other minor peers for Clonidine
- Amitriptyline
- Diltiazem
- Verapamil
- Haloperidol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.