Epinephrine and Oxytocin Interaction
Drug interaction information between Epinephrine and Oxytocin.
Epinephrine and Oxytocin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Epinephrine and Oxytocin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Oxytocin can increase the blood pressure-raising effects of epinephrine. This combination might cause your blood pressure to go higher than expected.
FDA Label Information
( 7 .1) Drugs that potentiate the effects of epinephrine include sympathomimetics, beta blockers, tricyclic antidepressants, MAO inhibitors, COMT inhibitors, clonidine, doxapram, oxytocin, levothyroxine sodium, and certain antihistamines. ( 7 .4) 7.1 Drugs Antagonizing Pressor Effects of Epinephrine • α-blockers, such as phentolamine • Vasodilators, such as nitrates • Diuretics • Antihypertensives • Ergot alkaloids • Phenothiazine antipsychotics 7.2 Drugs Potentiating Pressor Effects of Epinephrine • Sympathomimetics • β-blockers, such as propranolol • Tricyclic anti-depressants •...
Epinephrine Also Interacts With
- Tranylcypromine major
- Carbidopa/Levodopa moderate
- Digoxin moderate
- Imipramine moderate
- Levothyroxine minor
Frequently Asked Questions
What SPL severity band is on file for Epinephrine + Oxytocin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Epinephrine has 28 labeled pairs on file vs Oxytocin's 2. In the minor band specifically: Epinephrine has 24 (also Levothyroxine, Clonidine, Theophylline, Amitriptyline); Oxytocin has 2 (also Dopamine).
What mechanism field is on file for Epinephrine and Oxytocin?
Oxytocin can increase the blood pressure-raising effects of epinephrine. This combination might cause your blood pressure to go higher than expected.
Epinephrine carries more major-labeled pairs than Oxytocin
SPL source-record counts only. This page's band is minor · classes on file: Epinephrine (Adrenergic Agonist); Oxytocin (Oxytocic Hormone).
Epinephrine has 1 major-labeled pair vs Oxytocin's 0. This page itself is in the minor band, not the major band.
1 major · 3 moderate · 24 minor · 28 total
- Other minor peers for Epinephrine
- Levothyroxine
- Clonidine
- Theophylline
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.