Epinephrine and Amitriptyline Interaction
Drug interaction information between Epinephrine and Amitriptyline.
Epinephrine and Amitriptyline have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Epinephrine and Amitriptyline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs can affect your heart and nervous system in similar ways, which can lead to stronger effects than intended.
FDA Label Information
When amitriptyline is given with anticholinergic agents or sympathomimetic drugs, including epinephrine combined with local anesthetics, close supervision and careful adjustment of dosages are required.
Epinephrine Also Interacts With
- Tranylcypromine major
- Carbidopa/Levodopa moderate
- Digoxin moderate
- Imipramine moderate
- Levothyroxine minor
Amitriptyline Also Interacts With
- Risperidone major
- Sertraline minor
- Fluoxetine minor
- Paroxetine minor
- Disulfiram minor
Frequently Asked Questions
What SPL severity band is on file for Epinephrine + Amitriptyline?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Epinephrine has 28 labeled pairs on file vs Amitriptyline's 21. In the minor band specifically: Epinephrine has 24 (also Levothyroxine, Clonidine, Theophylline, Oxytocin); Amitriptyline has 20 (also Sertraline, Fluoxetine, Paroxetine, Disulfiram).
What mechanism field is on file for Epinephrine and Amitriptyline?
Both of these drugs can affect your heart and nervous system in similar ways, which can lead to stronger effects than intended.
Epinephrine's labeled portfolio outnumbers Amitriptyline
SPL source-record counts only. This page's band is minor · classes on file: Epinephrine (Adrenergic Agonist); Amitriptyline (Tricyclic Antidepressant (TCA)).
1 major · 3 moderate · 24 minor · 28 total
- Other minor peers for Epinephrine
- Levothyroxine
- Clonidine
- Theophylline
- Oxytocin
1 major · 0 moderate · 20 minor · 21 total
- Other minor peers for Amitriptyline
- Sertraline
- Fluoxetine
- Paroxetine
- Disulfiram
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.