Dutasteride and Paroxetine Interaction
Drug interaction information between Dutasteride and Paroxetine.
Dutasteride and Paroxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dutasteride and Paroxetine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Paroxetine stops the body from breaking down the medication properly, which can lead to higher amounts of the drug in your blood.
What To Do
Your doctor may need to monitor you for side effects or change your dose.
FDA Label Information
Concomitant treatment with paroxetine (a strong inhibitor of CYP2D6) resulted in increases in the C max and area under the concentration-time curve (AUC) of tamsulosin by factors of 1.3 and 1.6, respectively.
Dutasteride Also Interacts With
- Furosemide major
- Tamsulosin moderate
- Warfarin moderate
- Atenolol minor
- Diltiazem minor
Paroxetine Also Interacts With
- Linezolid major
- Pimozide major
- Thioridazine major
- Phenelzine moderate
- Tranylcypromine moderate
Frequently Asked Questions
Can I take Dutasteride and Paroxetine together?
This is a minor interaction. Your doctor may need to monitor you for side effects or change your dose.
How serious is the interaction between Dutasteride and Paroxetine?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Dutasteride and Paroxetine interact?
Paroxetine stops the body from breaking down the medication properly, which can lead to higher amounts of the drug in your blood.
Understanding the Dutasteride and Paroxetine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Dutasteride belongs to the 5-Alpha Reductase Inhibitor class and Paroxetine belongs to the Selective Serotonin Reuptake Inhibitor (SSRI) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Paroxetine stops the body from breaking down the medication properly, which can lead to higher amounts of the drug in your blood. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Dutasteride has 16 total documented interactions on file in this dataset, and Paroxetine has 51. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor may need to monitor you for side effects or change your dose. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Dutasteride or Paroxetine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.