Dutasteride and Diltiazem Interaction
Drug interaction information between Dutasteride and Diltiazem.
Dutasteride and Diltiazem have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dutasteride and Diltiazem. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Diltiazem makes it harder for the body to get rid of dutasteride, which leads to higher levels of the drug in your system.
What To Do
Your doctor should monitor you for side effects since the drug levels in your body may increase.
FDA Label Information
7.6 Calcium Channel Antagonists Dutasteride Coadministration of verapamil or diltiazem decreases dutasteride clearance and leads to increased exposure to dutasteride.
Dutasteride Also Interacts With
- Furosemide major
- Tamsulosin moderate
- Warfarin moderate
- Paroxetine minor
- Atenolol minor
Diltiazem Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Theophylline major
- Rifampin moderate
Frequently Asked Questions
Can I take Dutasteride and Diltiazem together?
This is a minor interaction. Your doctor should monitor you for side effects since the drug levels in your body may increase.
How serious is the interaction between Dutasteride and Diltiazem?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Dutasteride and Diltiazem interact?
Diltiazem makes it harder for the body to get rid of dutasteride, which leads to higher levels of the drug in your system.
Understanding the Dutasteride and Diltiazem Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Dutasteride belongs to the 5-Alpha Reductase Inhibitor class and Diltiazem belongs to the Calcium Channel Blocker class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Diltiazem makes it harder for the body to get rid of dutasteride, which leads to higher levels of the drug in your system. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Dutasteride has 16 total documented interactions on file in this dataset, and Diltiazem has 46. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should monitor you for side effects since the drug levels in your body may increase. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Dutasteride or Diltiazem based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.