Dutasteride and Diltiazem Interaction
Drug interaction information between Dutasteride and Diltiazem.
Dutasteride and Diltiazem have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dutasteride and Diltiazem. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Diltiazem makes it harder for the body to get rid of dutasteride, which leads to higher levels of the drug in your system.
FDA Label Information
7.6 Calcium Channel Antagonists Dutasteride Coadministration of verapamil or diltiazem decreases dutasteride clearance and leads to increased exposure to dutasteride.
Dutasteride Also Interacts With
- Furosemide major
- Tamsulosin moderate
- Warfarin moderate
- Paroxetine minor
- Atenolol minor
Diltiazem Also Interacts With
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Simvastatin major
- Theophylline major
- Rifampin moderate
Frequently Asked Questions
What SPL severity band is on file for Dutasteride + Diltiazem?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Diltiazem has 46 labeled pairs on file vs Dutasteride's 16. In the minor band specifically: Dutasteride has 13 (also Paroxetine, Atenolol, Nifedipine, Ketoconazole); Diltiazem has 35 (also Buspirone, Pravastatin, Lovastatin, Cyclosporine).
What mechanism field is on file for Dutasteride and Diltiazem?
Diltiazem makes it harder for the body to get rid of dutasteride, which leads to higher levels of the drug in your system.
Diltiazem carries more major-labeled pairs than Dutasteride
SPL source-record counts only. This page's band is minor · classes on file: Dutasteride (5-Alpha Reductase Inhibitor); Diltiazem (Calcium Channel Blocker).
Diltiazem has 4 major-labeled pairs vs Dutasteride's 1. This page itself is in the minor band, not the major band.
1 major · 2 moderate · 13 minor · 16 total
- Other minor peers for Dutasteride
- Paroxetine
- Atenolol
- Nifedipine
- Ketoconazole
4 major · 7 moderate · 35 minor · 46 total
- Other minor peers for Diltiazem
- Buspirone
- Pravastatin
- Lovastatin
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.