Dolutegravir/Lamivudine and Sucralfate Interaction
Drug interaction information between Dolutegravir/Lamivudine and Sucralfate.
Dolutegravir/Lamivudine and Sucralfate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dolutegravir/Lamivudine and Sucralfate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Sucralfate contains minerals that can bind to dolutegravir in your stomach, preventing the medicine from being absorbed into your bloodstream.
FDA Label Information
Medications containing polyvalent cations (e.g., Mg or Al): Cation-containing antacids a or laxatives Sucralfate Buffered medications ↓Dolutegravir Administer DOVATO 2 hours before or 6 hours after taking medications containing polyvalent cations.
Dolutegravir/Lamivudine Also Interacts With
- Dofetilide major
- Metformin moderate
- Oxcarbazepine moderate
- Phenytoin moderate
- Phenobarbital moderate
Sucralfate Also Interacts With
- Theophylline major
- Naproxen moderate
- Warfarin minor
- Ketoconazole minor
- Ciprofloxacin minor
Frequently Asked Questions
What SPL severity band is on file for Dolutegravir/Lamivudine + Sucralfate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sucralfate has 20 labeled pairs on file vs Dolutegravir/Lamivudine's 9. In the minor band specifically: Dolutegravir/Lamivudine has 4 (also Carbamazepine, Rifampin, Dolutegravir); Sucralfate has 18 (also Warfarin, Ketoconazole, Ciprofloxacin, Ofloxacin).
What mechanism field is on file for Dolutegravir/Lamivudine and Sucralfate?
Sucralfate contains minerals that can bind to dolutegravir in your stomach, preventing the medicine from being absorbed into your bloodstream.
Sucralfate's labeled portfolio outnumbers Dolutegravir/Lamivudine
SPL source-record counts only. This page's band is minor · classes on file: Dolutegravir/Lamivudine (Integrase Inhibitor / NRTI Combination); Sucralfate (Mucosal Protective Agent).
1 major · 4 moderate · 4 minor · 9 total
- Other minor peers for Dolutegravir/Lamivudine
- Carbamazepine
- Rifampin
- Dolutegravir
1 major · 1 moderate · 18 minor · 20 total
- Other minor peers for Sucralfate
- Warfarin
- Ketoconazole
- Ciprofloxacin
- Ofloxacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.