Dolutegravir/Lamivudine and Metformin Interaction
Drug interaction information between Dolutegravir/Lamivudine and Metformin.
Dolutegravir/Lamivudine and Metformin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Dolutegravir/Lamivudine and Metformin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Dolutegravir blocks the proteins that help your kidneys remove metformin, which can lead to higher levels of metformin in your blood.
FDA Label Information
7.2 Potential for DOVATO to Affect Other Drugs Dolutegravir, a component of DOVATO, inhibits the renal organic cation transporters (OCT)2 and multidrug and toxin extrusion transporter (MATE)1; thus, it may increase plasma concentrations of drugs eliminated via OCT2 or MATE1 such as dofetilide, dalfampridine, and metformin [see Contraindications ( 4 ), Drug Interactions ( 7.4 ), Clinical Pharmacology ( 12.3 )]. Antidiabetic: Metformin a ↑Metformin Refer to the prescribing information for metformin for assessing the benefit and risk of concomitant use of DOVATO and metformin.
Dolutegravir/Lamivudine Also Interacts With
- Dofetilide major
- Oxcarbazepine moderate
- Phenytoin moderate
- Phenobarbital moderate
- Carbamazepine minor
Metformin Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir moderate
- Empagliflozin moderate
- Empagliflozin/Linagliptin moderate
- Ertugliflozin moderate
- Linagliptin moderate
Frequently Asked Questions
What SPL severity band is on file for Dolutegravir/Lamivudine + Metformin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Metformin has 27 labeled pairs on file vs Dolutegravir/Lamivudine's 9. In the moderate band specifically: Dolutegravir/Lamivudine has 4 (also Oxcarbazepine, Phenytoin, Phenobarbital); Metformin has 10 (also Bictegravir, Empagliflozin, Empagliflozin/Linagliptin, Ertugliflozin).
What mechanism field is on file for Dolutegravir/Lamivudine and Metformin?
Dolutegravir blocks the proteins that help your kidneys remove metformin, which can lead to higher levels of metformin in your blood.
Dolutegravir/Lamivudine carries more major-labeled pairs than Metformin
SPL source-record counts only. This page's band is moderate · classes on file: Dolutegravir/Lamivudine (Integrase Inhibitor / NRTI Combination); Metformin (Biguanide).
Dolutegravir/Lamivudine has 1 major-labeled pair vs Metformin's 0. This page itself is in the moderate band, not the major band.
1 major · 4 moderate · 4 minor · 9 total
- Other moderate peers for Dolutegravir/Lamivudine
- Oxcarbazepine
- Phenytoin
- Phenobarbital
0 major · 10 moderate · 17 minor · 27 total
- Other moderate peers for Metformin
- Bictegravir
- Empagliflozin
- Empagliflozin/Linagliptin
- Ertugliflozin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.