Dolutegravir/Lamivudine and Carbamazepine Interaction
Drug interaction information between Dolutegravir/Lamivudine and Carbamazepine.
Dolutegravir/Lamivudine and Carbamazepine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dolutegravir/Lamivudine and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Carbamazepine speeds up the process of clearing dolutegravir from your system, which reduces the drug's effectiveness.
FDA Label Information
Anticonvulsant: Carbamazepine a ↓Dolutegravir An additional dolutegravir 50-mg dose should be taken, separated by 12 hours from DOVATO [see Dosage and Administration ( 2.3 )] .
Dolutegravir/Lamivudine Also Interacts With
- Dofetilide major
- Metformin moderate
- Oxcarbazepine moderate
- Phenytoin moderate
- Phenobarbital moderate
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Dolutegravir/Lamivudine + Carbamazepine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Dolutegravir/Lamivudine's 9. In the minor band specifically: Dolutegravir/Lamivudine has 4 (also Rifampin, Dolutegravir, Sucralfate); Carbamazepine has 110 (also Omeprazole, Ibuprofen, Citalopram, Amitriptyline).
What mechanism field is on file for Dolutegravir/Lamivudine and Carbamazepine?
Carbamazepine speeds up the process of clearing dolutegravir from your system, which reduces the drug's effectiveness.
Carbamazepine carries more major-labeled pairs than Dolutegravir/Lamivudine
SPL source-record counts only. This page's band is minor · classes on file: Dolutegravir/Lamivudine (Integrase Inhibitor / NRTI Combination); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Dolutegravir/Lamivudine's 1. This page itself is in the minor band, not the major band.
1 major · 4 moderate · 4 minor · 9 total
- Other minor peers for Dolutegravir/Lamivudine
- Rifampin
- Dolutegravir
- Sucralfate
3 major · 16 moderate · 110 minor · 129 total
- Other minor peers for Carbamazepine
- Omeprazole
- Ibuprofen
- Citalopram
- Amitriptyline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.