Dolutegravir/Lamivudine and Oxcarbazepine Interaction
Drug interaction information between Dolutegravir/Lamivudine and Oxcarbazepine.
Dolutegravir/Lamivudine and Oxcarbazepine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Dolutegravir/Lamivudine and Oxcarbazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Oxcarbazepine lowers the amount of dolutegravir in your body, which could make your HIV treatment less effective.
FDA Label Information
Anticonvulsants: Oxcarbazepine Phenytoin Phenobarbital ↓Dolutegravir Avoid coadministration with DOVATO because there are insufficient data to make dosing recommendations.
Dolutegravir/Lamivudine Also Interacts With
- Dofetilide major
- Metformin moderate
- Phenytoin moderate
- Phenobarbital moderate
- Carbamazepine minor
Oxcarbazepine Also Interacts With
- Tranylcypromine moderate
- Rifampin minor
- Phenytoin minor
- Phenobarbital minor
- Bictegravir/Emtricitabine/Tenofovir minor
Frequently Asked Questions
What SPL severity band is on file for Dolutegravir/Lamivudine + Oxcarbazepine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Oxcarbazepine has 18 labeled pairs on file vs Dolutegravir/Lamivudine's 9. In the moderate band specifically: Dolutegravir/Lamivudine has 4 (also Metformin, Phenytoin, Phenobarbital); Oxcarbazepine has 2 (also Tranylcypromine).
What mechanism field is on file for Dolutegravir/Lamivudine and Oxcarbazepine?
Oxcarbazepine lowers the amount of dolutegravir in your body, which could make your HIV treatment less effective.
Dolutegravir/Lamivudine carries more major-labeled pairs than Oxcarbazepine
SPL source-record counts only. This page's band is moderate · classes on file: Dolutegravir/Lamivudine (Integrase Inhibitor / NRTI Combination); Oxcarbazepine (Anticonvulsant).
Dolutegravir/Lamivudine has 1 major-labeled pair vs Oxcarbazepine's 0. This page itself is in the moderate band, not the major band.
1 major · 4 moderate · 4 minor · 9 total
- Other moderate peers for Dolutegravir/Lamivudine
- Metformin
- Phenytoin
- Phenobarbital
0 major · 2 moderate · 16 minor · 18 total
- Other moderate peers for Oxcarbazepine
- Tranylcypromine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.