Dolutegravir/Lamivudine and Rifampin Interaction
Drug interaction information between Dolutegravir/Lamivudine and Rifampin.
Dolutegravir/Lamivudine and Rifampin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dolutegravir/Lamivudine and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin makes your body process dolutegravir too quickly, leading to lower levels of the medication in your body.
FDA Label Information
Antimycobacterial: Rifampin a ↓Dolutegravir An additional 50-mg dose of dolutegravir should be taken, separated by 12 hours from DOVATO [see Dosage and Administration ( 2.3 )] .
Dolutegravir/Lamivudine Also Interacts With
- Dofetilide major
- Metformin moderate
- Oxcarbazepine moderate
- Phenytoin moderate
- Phenobarbital moderate
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Dolutegravir/Lamivudine + Rifampin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Dolutegravir/Lamivudine's 9. In the minor band specifically: Dolutegravir/Lamivudine has 4 (also Carbamazepine, Dolutegravir, Sucralfate); Rifampin has 103 (also Metoprolol, Losartan, Simvastatin, Glipizide).
What mechanism field is on file for Dolutegravir/Lamivudine and Rifampin?
Rifampin makes your body process dolutegravir too quickly, leading to lower levels of the medication in your body.
Rifampin carries more major-labeled pairs than Dolutegravir/Lamivudine
SPL source-record counts only. This page's band is minor · classes on file: Dolutegravir/Lamivudine (Integrase Inhibitor / NRTI Combination); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Dolutegravir/Lamivudine's 1. This page itself is in the minor band, not the major band.
1 major · 4 moderate · 4 minor · 9 total
- Other minor peers for Dolutegravir/Lamivudine
- Carbamazepine
- Dolutegravir
- Sucralfate
8 major · 26 moderate · 103 minor · 137 total
- Other minor peers for Rifampin
- Metoprolol
- Losartan
- Simvastatin
- Glipizide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.