Dolutegravir/Lamivudine and Dolutegravir Interaction
Drug interaction information between Dolutegravir/Lamivudine and Dolutegravir.
Dolutegravir/Lamivudine and Dolutegravir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dolutegravir/Lamivudine and Dolutegravir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Dolutegravir blocks the specific pathways in the kidneys used to remove certain medicines, which can cause those other drugs to build up in your body.
FDA Label Information
7.2 Potential for DOVATO to Affect Other Drugs Dolutegravir, a component of DOVATO, inhibits the renal organic cation transporters (OCT)2 and multidrug and toxin extrusion transporter (MATE)1; thus, it may increase plasma concentrations of drugs eliminated via OCT2 or MATE1 such as dofetilide, dalfampridine, and metformin [see Contraindications ( 4 ), Drug Interactions ( 7.4 ), Clinical Pharmacology ( 12.3 )]. 7.3 Potential for Other Drugs to Affect the Components of DOVATO Dolutegravir is metabolized by uridine diphosphate (UDP)-glucuronosyl transferase (UGT)1A1 with some contribution...
Dolutegravir/Lamivudine Also Interacts With
- Dofetilide major
- Metformin moderate
- Oxcarbazepine moderate
- Phenytoin moderate
- Phenobarbital moderate
Dolutegravir Also Interacts With
- Dofetilide major
- Empagliflozin moderate
- Empagliflozin/Linagliptin moderate
- Ertugliflozin moderate
- Linagliptin moderate
Frequently Asked Questions
What SPL severity band is on file for Dolutegravir/Lamivudine + Dolutegravir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dolutegravir has 28 labeled pairs on file vs Dolutegravir/Lamivudine's 9. In the minor band specifically: Dolutegravir/Lamivudine has 4 (also Carbamazepine, Rifampin, Sucralfate); Dolutegravir has 21 (also Omeprazole, Prednisone, Estradiol, Carbamazepine).
What mechanism field is on file for Dolutegravir/Lamivudine and Dolutegravir?
Dolutegravir blocks the specific pathways in the kidneys used to remove certain medicines, which can cause those other drugs to build up in your body.
Dolutegravir's labeled portfolio outnumbers Dolutegravir/Lamivudine
SPL source-record counts only. This page's band is minor · classes on file: Dolutegravir/Lamivudine (Integrase Inhibitor / NRTI Combination); Dolutegravir (Integrase Strand Transfer Inhibitor).
1 major · 4 moderate · 4 minor · 9 total
- Other minor peers for Dolutegravir/Lamivudine
- Carbamazepine
- Rifampin
- Sucralfate
1 major · 6 moderate · 21 minor · 28 total
- Other minor peers for Dolutegravir
- Omeprazole
- Prednisone
- Estradiol
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.