Mefenamic Acid and Meloxicam Interaction
Drug interaction information between Mefenamic Acid and Meloxicam.
Mefenamic Acid and Meloxicam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Mefenamic Acid and Meloxicam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs are NSAIDs that work in the same way, so taking them together increases the risk of stomach issues without helping more with pain.
FDA Label Information
In the absence of data regarding potential interaction between pemetrexed and NSAIDs with longer half-lives (e.g., meloxicam, nabumetone), patients taking these NSAIDs should interrupt dosing for at least five days before, the day of, and two days following pemetrexed administration.
Mefenamic Acid Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Warfarin moderate
- Furosemide minor
- Aspirin minor
Meloxicam Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Furosemide minor
- Aspirin minor
- Propranolol minor
Frequently Asked Questions
What SPL severity band is on file for Mefenamic Acid + Meloxicam?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Meloxicam has 17 labeled pairs on file vs Mefenamic Acid's 15. In the minor band specifically: Mefenamic Acid has 12 (also Furosemide, Aspirin, Propranolol, Diclofenac); Meloxicam has 15 (also Furosemide, Aspirin, Propranolol, Warfarin).
What mechanism field is on file for Mefenamic Acid and Meloxicam?
Both of these drugs are NSAIDs that work in the same way, so taking them together increases the risk of stomach issues without helping more with pain.
Meloxicam's labeled portfolio outnumbers Mefenamic Acid
SPL source-record counts only. This page's band is minor · classes on file: Mefenamic Acid (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Meloxicam (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
0 major · 3 moderate · 12 minor · 15 total
- Other minor peers for Mefenamic Acid
- Furosemide
- Aspirin
- Propranolol
- Diclofenac
0 major · 2 moderate · 15 minor · 17 total
- Other minor peers for Meloxicam
- Furosemide
- Aspirin
- Propranolol
- Warfarin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.