Mefenamic Acid and Aspirin Interaction
Drug interaction information between Mefenamic Acid and Aspirin.
Mefenamic Acid and Aspirin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Mefenamic Acid and Aspirin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these two drugs together does not provide extra pain relief but does increase your risk of dangerous bleeding.
FDA Label Information
Intervention: Monitor patients with concomitant use of mefenamic acid with anticoagulants (e.g.,warfarin), antiplatelet agents (e.g., aspirin), selective serotonin reuptake inhibitors (SSRIs), and serotonin norepinephrine reuptake inhibitors (SNRIs) for signs of bleeding (see Warnings ; Hematologic Toxicity ) . Aspirin Clinical Impact: Controlled clinical studies showed that the concomitant use of NSAIDs and analgesic doses of aspirin does not produce any greater therapeutic effect than the use of NSAIDs alone. In a clinical study, the concomitant use of an NSAID and aspirin was associated...
Mefenamic Acid Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Warfarin moderate
- Meloxicam minor
- Furosemide minor
Aspirin Also Interacts With
- Atenolol major
- Fluoxetine major
- Ibandronate major
- Alendronate moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Mefenamic Acid + Aspirin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aspirin has 47 labeled pairs on file vs Mefenamic Acid's 15. In the minor band specifically: Mefenamic Acid has 12 (also Meloxicam, Furosemide, Propranolol, Diclofenac); Aspirin has 32 (also Carisoprodol, Celecoxib, Colestipol, Diflunisal).
What mechanism field is on file for Mefenamic Acid and Aspirin?
Using these two drugs together does not provide extra pain relief but does increase your risk of dangerous bleeding.
Aspirin carries more major-labeled pairs than Mefenamic Acid
SPL source-record counts only. This page's band is minor · classes on file: Mefenamic Acid (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Aspirin (Antiplatelet / NSAID).
Aspirin has 3 major-labeled pairs vs Mefenamic Acid's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 12 minor · 15 total
- Other minor peers for Mefenamic Acid
- Meloxicam
- Furosemide
- Propranolol
- Diclofenac
3 major · 12 moderate · 32 minor · 47 total
- Other minor peers for Aspirin
- Carisoprodol
- Celecoxib
- Colestipol
- Diflunisal
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.