Mefenamic Acid and Propranolol Interaction
Drug interaction information between Mefenamic Acid and Propranolol.
Mefenamic Acid and Propranolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Mefenamic Acid and Propranolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Mefenamic acid can interfere with how propranolol works, making it less effective at lowering your blood pressure.
FDA Label Information
ACE Inhibitors, Angiotensin Receptor Blockers, and Beta-Blockers Clinical Impact: NSAIDs may diminish the antihypertensive effect of angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), or beta-blockers (including propranolol).
Mefenamic Acid Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Warfarin moderate
- Meloxicam minor
- Furosemide minor
Frequently Asked Questions
What SPL severity band is on file for Mefenamic Acid + Propranolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Propranolol has 44 labeled pairs on file vs Mefenamic Acid's 15. In the minor band specifically: Mefenamic Acid has 12 (also Meloxicam, Furosemide, Aspirin, Diclofenac); Propranolol has 44 (also Clonidine, Diltiazem, Warfarin, Verapamil).
What mechanism field is on file for Mefenamic Acid and Propranolol?
Mefenamic acid can interfere with how propranolol works, making it less effective at lowering your blood pressure.
Propranolol's labeled portfolio outnumbers Mefenamic Acid
SPL source-record counts only. This page's band is minor · classes on file: Mefenamic Acid (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Propranolol (Non-Selective Beta-Blocker).
0 major · 3 moderate · 12 minor · 15 total
- Other minor peers for Mefenamic Acid
- Meloxicam
- Furosemide
- Aspirin
- Diclofenac
0 major · 0 moderate · 44 minor · 44 total
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.