Dexamethasone and Warfarin Interaction
Drug interaction information between Dexamethasone and Warfarin.
Dexamethasone and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dexamethasone and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Dexamethasone can interfere with how warfarin works, often making it less effective. This could make your blood more likely to clot.
FDA Label Information
Anticoagulants, Oral: Co-administration of corticosteroids and warfarin usually results in inhibition of response to warfarin, although there have been some conflicting reports.
Dexamethasone Also Interacts With
- Aspirin moderate
- Ketoconazole moderate
- Nirmatrelvir/Ritonavir moderate
- Cyclosporine minor
- Hydrocortisone minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Dexamethasone + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Dexamethasone's 21. In the minor band specifically: Dexamethasone has 18 (also Cyclosporine, Hydrocortisone, Erythromycin, Rifampin); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Dexamethasone and Warfarin?
Dexamethasone can interfere with how warfarin works, often making it less effective. This could make your blood more likely to clot.
Warfarin carries more major-labeled pairs than Dexamethasone
SPL source-record counts only. This page's band is minor · classes on file: Dexamethasone (Corticosteroid); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Dexamethasone's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 18 minor · 21 total
- Other minor peers for Dexamethasone
- Cyclosporine
- Hydrocortisone
- Erythromycin
- Rifampin
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.