Dexamethasone and Nirmatrelvir/Ritonavir Interaction
Drug interaction information between Dexamethasone and Nirmatrelvir/Ritonavir.
Dexamethasone and Nirmatrelvir/Ritonavir have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Dexamethasone and Nirmatrelvir/Ritonavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ritonavir blocks the enzyme that breaks down dexamethasone, which can cause the steroid to build up to high levels in your body.
FDA Label Information
Corticosteroids primarily metabolized by CYP3A betamethasone, budesonide, ciclesonide, dexamethasone, fluticasone, methylprednisolone, mometasone, triamcinolone ↑ corticosteroid Co-administration with corticosteroids (all routes of administration) of which exposures are significantly increased by strong CYP3A inhibitors can increase the risk for Cushing’s syndrome and adrenal suppression.
Dexamethasone Also Interacts With
- Aspirin moderate
- Ketoconazole moderate
- Warfarin minor
- Cyclosporine minor
- Hydrocortisone minor
Nirmatrelvir/Ritonavir Also Interacts With
- Simvastatin major
- Lovastatin major
- Sildenafil major
- Carbamazepine major
- Rifampin major
Frequently Asked Questions
What SPL severity band is on file for Dexamethasone + Nirmatrelvir/Ritonavir?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Dexamethasone's 21. In the moderate band specifically: Dexamethasone has 3 (also Aspirin, Ketoconazole); Nirmatrelvir/Ritonavir has 30 (also Amlodipine, Tamsulosin, Fluticasone, Apixaban).
What mechanism field is on file for Dexamethasone and Nirmatrelvir/Ritonavir?
Ritonavir blocks the enzyme that breaks down dexamethasone, which can cause the steroid to build up to high levels in your body.
Nirmatrelvir/Ritonavir carries more major-labeled pairs than Dexamethasone
SPL source-record counts only. This page's band is moderate · classes on file: Dexamethasone (Corticosteroid); Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)).
Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Dexamethasone's 0. This page itself is in the moderate band, not the major band.
0 major · 3 moderate · 18 minor · 21 total
- Other moderate peers for Dexamethasone
- Aspirin
- Ketoconazole
23 major · 30 moderate · 33 minor · 86 total
- Other moderate peers for Nirmatrelvir/Ritonavir
- Amlodipine
- Tamsulosin
- Fluticasone
- Apixaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.