Dexamethasone and Erythromycin Interaction
Drug interaction information between Dexamethasone and Erythromycin.
Dexamethasone and Erythromycin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Dexamethasone and Erythromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Erythromycin slows down the process that removes dexamethasone from your body, which can increase steroid levels. Dexamethasone can also cause erythromycin to leave your body faster than usual.
FDA Label Information
Drugs which inhibit CYP 3A4 (e.g., ketoconazole, macrolide antibiotics such as erythromycin) have the potential to result in increased plasma concentrations of corticosteroids. Co-adminstration with other drugs that are metabolized by CYP 3A4 (e.g., indinavir, erythromycin) may increase their clearance, resulting in decreased plasma concentration.
Dexamethasone Also Interacts With
- Aspirin moderate
- Ketoconazole moderate
- Nirmatrelvir/Ritonavir moderate
- Warfarin minor
- Cyclosporine minor
Erythromycin Also Interacts With
- Eplerenone major
- Pitavastatin major
- Risperidone major
- Sildenafil major
- Lefamulin moderate
Frequently Asked Questions
What SPL severity band is on file for Dexamethasone + Erythromycin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Erythromycin has 63 labeled pairs on file vs Dexamethasone's 21. In the minor band specifically: Dexamethasone has 18 (also Warfarin, Cyclosporine, Hydrocortisone, Rifampin); Erythromycin has 53 (also Acetaminophen/Oxycodone, Alprazolam, Atorvastatin, Bromocriptine).
What mechanism field is on file for Dexamethasone and Erythromycin?
Erythromycin slows down the process that removes dexamethasone from your body, which can increase steroid levels. Dexamethasone can also cause erythromycin to leave your body faster than usual.
Erythromycin carries more major-labeled pairs than Dexamethasone
SPL source-record counts only. This page's band is minor · classes on file: Dexamethasone (Corticosteroid); Erythromycin (Macrolide Antibiotic).
Erythromycin has 4 major-labeled pairs vs Dexamethasone's 0. This page itself is in the minor band, not the major band.
0 major · 3 moderate · 18 minor · 21 total
- Other minor peers for Dexamethasone
- Warfarin
- Cyclosporine
- Hydrocortisone
- Rifampin
4 major · 6 moderate · 53 minor · 63 total
- Other minor peers for Erythromycin
- Acetaminophen/Oxycodone
- Alprazolam
- Atorvastatin
- Bromocriptine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.